Multiple control of interleukin-8 gene expression

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Chemokines

2000 • 3,773 citations

NF-κB: Ten Years After

1996 • 3,008 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

AP-1 function and regulation

1997 • 2,833 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

Interleukin‐8, a chemotactic and inflammatory cytokine

1992 • 941 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism

1999 • 772 citations

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

1998 • 723 citations

Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

1997 • 686 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity

1999 • 616 citations

The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

2000 • 550 citations

The Enhanceosome and Transcriptional Synergy

1998 • 545 citations

NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter

1993 • 504 citations

Molecular mechanism of interleukin-8 gene expression

1994 • 465 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti

2000 • 435 citations

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

1998 • 433 citations

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.

1994 • 423 citations

Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells.

1997 • 410 citations

Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB

1993 • 400 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

1999 • 384 citations

Activation of the p38 Mitogen-activated Protein Kinase Pathway by Epstein-Barr Virus-encoded Latent Membrane Protein 1 Coregulates Interleukin-6 and Interleukin-8 Production

1999 • 347 citations

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.

1994 • 327 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways

1999 • 295 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

Osmotic regulation of cytokine synthesis in vitro.

1995 • 282 citations

Involvement of the Transcription Factor NF-κB in Tubular Morphogenesis of Human Microvascular Endothelial Cells by Oxidative Stress

1996 • 278 citations

Deficiency of the Stress Kinase P38α Results in Embryonic Lethality

2000 • 272 citations

Inhibition of MAP Kinase Kinase Prevents Cytokine and Prostaglandin E2 Production in Lipopolysaccharide-Stimulated Monocytes

1998 • 255 citations

Oct-1 and CCAAT/Enhancer-binding Protein (C/EBP) Bind to Overlapping Elements within the Interleukin-8 Promoter

1997 • 231 citations

Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression

1997 • 231 citations

A novel DNA recognition mode by the NF-κB p65 homodimer

1998 • 229 citations

JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

1998 • 217 citations

Regulation of IL-6 and IL-8 Expression in Rheumatoid Arthritis Synovial Fibroblasts: the Dominant Role for NF-κB But Not C/EBPβ or c-Jun

2000 • 210 citations

Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit

1997 • 208 citations

Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH2-terminal Kinase (JNK/SAPK)

1998 • 200 citations

p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

2000 • 192 citations

The role of p38 mitogen‐activated protein kinase in IL‐6 and IL‐8 production from the TNF‐α‐ or IL‐1β‐stimulated rheumatoid synovial fibroblasts

1999 • 180 citations

SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes

1998 • 171 citations

Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells

2000 • 171 citations

A Promoter Recruitment Mechanism for Tumor Necrosis Factor-α-induced Interleukin-8 Transcription in Type II Pulmonary Epithelial Cells

1998 • 170 citations

Interaction of the COOH-terminal Transactivation Domain of p65 NF-κB with TATA-binding Protein, Transcription Factor IIB, and Coactivators

1995 • 157 citations

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

1999 • 152 citations

Role of p38 Mitogen-Activated Protein Kinase in Rhinovirus-Induced Cytokine Production by Bronchial Epithelial Cells

2000 • 149 citations

Prostaglandin E2 Stimulates IL-8 Gene Expression in Human Colonic Epithelial Cells by a Posttranscriptional Mechanism

1998 • 147 citations

Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene

1997 • 146 citations

Assembly of a Functional Beta Interferon Enhanceosome Is Dependent on ATF-2–c-jun Heterodimer Orientation

2000 • 136 citations

Activator Protein‐1 Is the Preferred Transcription Factor for Cooperative Interaction with Nuclear Factor‐kB in Respiratory Syncytial Virus‐Induced Interleukin‐8 Gene Expression in Airway Epithelium

1998 • 131 citations

The NF-κB Repressing Factor Is Involved in Basal Repression and Interleukin (IL)-1-induced Activation of IL-8 Transcription by Binding to a Conserved NF-κB-flanking Sequence Element

2001 • 127 citations

NF-κB Regulation by IκB Kinase-2 in Rheumatoid Arthritis Synoviocytes

2001 • 125 citations

Alcohol (Ethanol) Inhibits IL-8 and TNF: Role of the p38 Pathway

1999 • 115 citations

Extracellular signal–regulated kinase 1/extracellular signal–regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor κB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells

2000 • 111 citations

Synergistic Activation of Interleukin-8 Gene Transcription by All-trans-retinoic Acid and Tumor Necrosis Factor-α Involves the Transcription Factor NF-κB

1996 • 110 citations

Constitutive silencing of IFN-β promoter is mediated by NRF (NF-κB-repressing factor), a nuclear inhibitor of NF-κB

1999 • 106 citations

Stimulation of Interleukin-8 Production by Okadaic Acid and Vanadate in a Human Promyelocyte Cell Line, an HL-60 Subline

1997 • 104 citations

The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment

2001 • 103 citations

Stress-activated Protein Kinase/Jun N-terminal Kinase Is Required for Interleukin (IL)-1-induced IL-6 and IL-8 Gene Expression in the Human Epidermal Carcinoma Cell Line KB

1998 • 100 citations

The MAPK Kinase Kinase TAK1 Plays a Central Role in Coupling the Interleukin-1 Receptor to Both Transcriptional and RNA-targeted Mechanisms of Gene Regulation

2001 • 99 citations

RAC1/P38 MAPK Signaling Pathway Controls β1 Integrin–Induced Interleukin-8 Production in Human Natural Killer Cells

2000 • 99 citations

Identification of Tumor-Specific Paclitaxel (Taxol)-Responsive Regulatory Elements in the Interleukin-8 Promoter

1997 • 90 citations

Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-κB activity

2000 • 76 citations

Cooling and Rewarming-Induced IL-8 Expression in Human Bronchial Epithelial Cells through p38 MAP Kinase-Dependent Pathway

1998 • 75 citations

ACTIVATION OF ERK2 BY RESPIRATORY SYNCYTIAL VIRUS IN A549 CELLS IS LINKED TO THE PRODUCTION OF INTERLEUKIN 8

2000 • 71 citations

Interferon-beta promoters contain a DNA element that acts as a position-independent silencer on the NF-kappa B site.

1993 • 69 citations

TNF Receptor-Associated Factor-2 Is Involved in Both IL-1β and TNF-α Signaling Cascades Leading to NF-κB Activation and IL-8 Expression in Human Intestinal Epithelial Cells

1999 • 67 citations

Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2

2001 • 62 citations

Modulation of Tumor Necrosis Factor and Interleukin-1-dependent NF-κB Activity by mPLK/IRAK

1999 • 58 citations

Endothelin-1–Induced Interleukin-8 Production in Human Brain-Derived Endothelial Cells Is Mediated by the Protein Kinase C and Protein Tyrosine Kinase Pathways

1999 • 43 citations

Nitric Oxide Suppresses IL-8 Transcription by Inhibiting C-Jun N-Terminal Kinase-Induced AP-1 Activation

2001 • 36 citations

Regulation of interleukin-8 gene expression after phagocytosis of zymosan by human monocytic cells

2001 • 35 citations

Differential involvement of p38 mitogen-activated protein kinase and phosphatidyl inositol 3-kinase in the IL-1-mediated NF-κB and AP-1 activation

2001 • 33 citations

The Transcriptional Silencer Protein NRF: A Repressor of NF-κB Enhancers

1997 • 23 citations

Evidence for Epigenetic Mechanisms That Silence Both Basal and Immune-Stimulated Transcription of the IL-8 Gene

2001 • 23 citations