Differential involvement of p38 mitogen-activated protein kinase and phosphatidyl inositol 3-kinase in the IL-1-mediated NF-κB and AP-1 activation

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

AP-1 function and regulation

1997 • 2,833 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter

1993 • 504 citations

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.

1994 • 423 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

Tumor Necrosis Factor ä-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways

1997 • 355 citations

FAK Is the Upstream Signal Protein of the Phosphatidylinositol 3-Kinase-Akt Survival Pathway in Hydrogen Peroxide-induced Apoptosis of a Human Glioblastoma Cell Line

1999 • 252 citations

Phosphatidylinositol 3-Kinase in Interleukin 1 Signaling

1997 • 231 citations

IL-1 Receptor Accessory Protein Is an Essential Component of the IL-1 Receptor

1998 • 169 citations

IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line.

1991 • 166 citations

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

1994 • 140 citations

Stimulation of Interleukin-8 Production by Okadaic Acid and Vanadate in a Human Promyelocyte Cell Line, an HL-60 Subline

1997 • 104 citations

Proinflammatory cytokine–induced and chemical mediator–induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase–dependent pathway☆☆☆★

1998 • 99 citations

Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I

1998 • 75 citations

Pro-inflammatory Cytokines Stimulate Mitogen-activated Protein Kinase Subfamilies, Increase Phosphorylation of c-Jun and ATF2 and Upregulate c-Jun Protein in Neonatal Rat Ventricular Myocytes

1999 • 73 citations

THE MITOGEN-ACTIVATED PROTEIN KINASE p38 IS NECESSARY FOR INTERLEUKIN-1β-INDUCED MONOCYTE CHEMOATTRACTANT PROTEIN 1 EXPRESSION BY HUMAN MESANGIAL CELLS

1999 • 67 citations

The Effects of IL-1 on Mitogen-Activated Protein Kinases in Rabbit Articular Chondrocytes

1997 • 53 citations

Induction and regulation of IL-8 and MCAF production in human brain tumor cell lines and brain tumor tissues.

1993 • 39 citations

A New Platelet-Derived Growth Factor-Regulated Genomic Element Which Binds a Serine/Threonine Phosphoprotein Mediates Induction of the Slow Immediate-Early Gene MCP-1

1995 • 39 citations

Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: involvement of monocyte-derived interleukin-1alpha.

1998 • 22 citations