Nitric Oxide Suppresses IL-8 Transcription by Inhibiting C-Jun N-Terminal Kinase-Induced AP-1 Activation

AP-1 function and regulation

1997 • 2,833 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Interleukin‐8, a chemotactic and inflammatory cytokine

1992 • 941 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

1993 • 529 citations

NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter

1993 • 504 citations

Inhibition of NF- B DNA Binding by Nitric Oxide

1996 • 479 citations

Molecular mechanism of interleukin-8 gene expression

1994 • 465 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

1992 • 450 citations

Regulation of Interleukin-8 Gene Expression

1999 • 410 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

NF-kappa B subunit-specific regulation of the interleukin-8 promoter.

1993 • 369 citations

Cytokine-mediated Transcriptional Induction of the Human Inducible Nitric Oxide Synthase Gene Requires Both Activator Protein 1 and Nuclear Factor κB-binding Sites

1998 • 309 citations

Chemokines and tissue injury.

1995 • 303 citations

Interleukin-8 gene expression in human bronchial epithelial cells.

1991 • 260 citations

Inhibition of Endothelial Vascular Cell Adhesion Molecule-1 Expression by Nitric Oxide Involves the Induction and Nuclear Translocation of IκBα

1997 • 250 citations

Oct-1 and CCAAT/Enhancer-binding Protein (C/EBP) Bind to Overlapping Elements within the Interleukin-8 Promoter

1997 • 231 citations

Mechanism of action of a dominant-negative mutant of c-Jun.

1994 • 207 citations

Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation.

1996 • 187 citations

NF-κB and AP-1 Activation by Nitric Oxide Attenuated Apoptotic Cell Death in RAW 264.7 Macrophages

1999 • 157 citations

Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8.

1997 • 154 citations

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

1994 • 140 citations

Properties of Pro‐Inflammatory Cell Type‐Specific Leukocyte Chemotactic Cytokines, Interleukin 8 (IL‐8) and Monocyte Chemotactic and Activating Factor (MCAF)

1992 • 135 citations

Activator Protein‐1 Is the Preferred Transcription Factor for Cooperative Interaction with Nuclear Factor‐kB in Respiratory Syncytial Virus‐Induced Interleukin‐8 Gene Expression in Airway Epithelium

1998 • 131 citations

Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

1997 • 123 citations

Inhibition of AP-1 DNA Binding by Nitric Oxide Involving Conserved Cysteine Residues in Jun and Fos

1998 • 119 citations

Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites.

1998 • 73 citations

Expression of recombinant rabbit IL-8 in Escherichia coli and establishment of the essential involvement of IL-8 in recruiting neutrophils into lipopolysaccharide-induced inflammatory site of rabbit skin

1993 • 72 citations

Nitric Oxide Inhibits c-Jun N-Terminal Kinase 2 (JNK2) via S-Nitrosylation

1998 • 72 citations

Differential effects of nitric oxide–mediated S-nitrosylation on p50 and c-jun DNA binding

1998 • 55 citations

Nitric Oxide Modulates the c-Jun N-terminal Kinase/Stress-Activated Protein Kinase Activity through Activating c-Jun N-Terminal Kinase Kinase

1997 • 53 citations

[35] Methods for analyzing c-Jun kinase

1995 • 52 citations

CCAAT Box Enhancer Binding Protein α (C/EBP-α) Stimulates B Element-mediated Transcription in Transfected Cells

1996 • 40 citations

Nitric oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-kappaB binding to DNA: effects on endothelial function.

1999 • 36 citations

Regulation of Human Interleukin 8 Gene Expression and Binding of Several Other Members of the Intercrine Family to Receptors for Interleukin-8

1991 • 35 citations

Nitric oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-κB binding to DNA: effects on endothelial function

1999 • 26 citations

Intradermal challenge with interleukin‐8 causes tissue oedema and neutrophil accumulation in atopic and non‐atopic human subjects

1996 • 13 citations