Interferon-beta promoters contain a DNA element that acts as a position-independent silencer on the NF-kappa B site.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

A new dominant hybrid selective marker for higher eukaryotic cells

1981 • 662 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

The human β-interferon gene enhancer is under negative control

1986 • 395 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene

1986 • 252 citations

Overlapping positive and negative regulatory domains of the human beta-interferon gene.

1988 • 237 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene

1985 • 216 citations

Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor.

1984 • 199 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer

1989 • 135 citations

Reversible silencing of enhancers by sequences derived from the human IFN-α promoter

1987 • 119 citations

Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1

1990 • 114 citations

An ATF/CREB binding site is required for virus induction of the human interferon beta gene [corrected]

1992 • 107 citations

The same 50-kDa cellular protein binds to the negative regulatory elements of the interleukin 2 receptor alpha-chain gene and the human immunodeficiency virus type 1 long terminal repeat.

1989 • 67 citations

Gene shuttling: moving of cloned DNA into and out of eukaryotic cells

1982 • 51 citations

Cooperative interaction of multiple DNA elements in the human interferon-beta promoter

1987 • 39 citations

Isolation and Functional Characterization of the Murine Interferon-β1 Promoter

1989 • 27 citations

UV cross-linking of distinct proteins to the PRDII domain of the interferon-β promoter

1990 • 8 citations