Histamine H₁-Receptor Activation of Nuclear Factor-κB: Roles for Gβγ- and Gα_q/11-Subunits in Constitutive and Agonist-Mediated Signaling

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Inflammatory mediators of asthma: an update.

1998 • 719 citations

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

1998 • 502 citations

Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

1998 • 422 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1995 • 285 citations

The Nuclear Factor κ-B Signaling Pathway Participates in Dysregulation of Vascular Smooth Muscle Cells in Vitroand in Human Atherosclerosis

1997 • 265 citations

Cardiac Actions of Antihistamines

1996 • 261 citations

Constitutive Signaling of the Human Cytomegalovirus-encoded Chemokine Receptor US28

2001 • 239 citations

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

1996 • 235 citations

NF-kB: a pivotal role in asthma and a new target for therapy

1997 • 218 citations

Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

1993 • 186 citations

Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α

1999 • 180 citations

G PROTEIN SUBUNITS

1997 • 168 citations

Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists

2000 • 162 citations

Agonist-independent regulation of constitutively active G-protein-coupled receptors

1998 • 150 citations

Inverse agonism and the regulation of receptor number

1997 • 142 citations

Activation of NF-κB by Bradykinin through a Gαq- and Gβγ-dependent Pathway That Involves Phosphoinositide 3-Kinase and Akt

2000 • 138 citations

Molecular Cloning of the Human Histamine H1 Receptor Gene

1994 • 136 citations

[Ca2+] Oscillation Frequency Regulates Agonist-stimulated NF-κB Transcriptional Activity

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Pharmacology of α fluoromethylhistidine, a specific inhibitor of histidine decarboxylase

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Guinea Pig Histamine H₁ Receptor. II. Stable Expression in Chinese Hamster Ovary Cells Reveals the Interaction with Three Major Signal Transduction Pathways

1994 • 110 citations

G Proteins endogenously expressed in Sf 9 cells: interactions with mammalian histamine receptors

1997 • 95 citations

Increased expression of histamine H₁ receptor mRNA in allergic rhinitis

1996 • 92 citations

Expression of Histamine Receptors in Nasal Epithelial Cells and Endothelial Cells – The Effects of Sex Hormones

1998 • 89 citations

Lysophosphatidic Acid Activates NF-κB in Fibroblasts

1999 • 82 citations

Constitutive activation of muscarinic receptors by the G‐protein G_q

1995 • 73 citations

Inverse agonist-induced up-regulation of the human beta2-adrenoceptor in transfected neuroblastoma X glioma hybrid cells.

1996 • 72 citations

Constitutive Activity and Structural Instability of the Wild‐Type Human H₂ Receptor

1998 • 68 citations

Synthesis and Histamine H1 Receptor Agonist Activity of a Series of 2-Phenylhistamines, 2-Heteroarylhistamines, and Analogs

1995 • 66 citations

Leukotriene B₄mediates histamine induction of NF-κB and IL-8 in human bronchial epithelial cells

1998 • 63 citations

Expression of the histamine H1 receptor gene in relation to atherosclerosis.

1995 • 53 citations

Characterization of transducin from bovine retinal rod outer segments. Use of monoclonal antibodies to probe the structure and function of the subunit.

1988 • 51 citations

Pharmacological and Functional Characterisation of the Wild—Type and Site—Directed Mutants of the Human H₁Histamine Receptor Stably Expressed in CHO Cells

1995 • 46 citations

Therapeutic advantages of third generation antihistamines

1998 • 45 citations

Histamine H1 receptor antagonists

2013 • 27 citations

The role of phosphatidylinositide‐3‐kinase in basal mitogen‐activated protein kinase activity and cell survival

1999 • 24 citations

Endogenous ligands and inverse agonism

1995 • 15 citations

Histamine H2 receptor antagonists

2015 • 6 citations