Constitutive activation of muscarinic receptors by the G‐protein G_q

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

Muscarinic Receptors—Characterization, coupling and function

1993 • 1,264 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.

1992 • 285 citations

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands.

1994 • 249 citations

A Prospectus for Multispectral-Multiplex DNA Sequencing

1989 • 233 citations

Diurnal Expression of Transducin mRNA and Translocation of Transducin in Rods of Rat Retina

1987 • 231 citations

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

1994 • 224 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

Determinants of alpha 2-adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G protein state.

1994 • 149 citations

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.

1993 • 145 citations

The transforming activity of activated Gα12

1993 • 100 citations

Antagonists of bradykinin that stabilize a G-protein-uncoupled state of the B2 receptor act as inverse agonists in rat myometrial cells

1994 • 83 citations

Structure-Function of Muscarinic Receptor Coupling to G Proteins

1995 • 80 citations

Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes

1992 • 72 citations

Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq α/G11 α following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells

1993 • 60 citations

Muscarinic Acetylcholine Receptors

1992 • 40 citations

Low density lipoproteins induce parasympathetic responsiveness in embryonic chick ventricular myocytes in parallel with a coordinate increase in expression of genes coding for the M2 muscarinic receptor, G alpha i2, and the acetylcholine-sensitive K+ channel.

1994 • 17 citations

Molecular biology of G-protein-coupled receptors

1993 • 16 citations