Therapeutic advantages of third generation antihistamines

Physicians Desk Reference

1994 • 2,653 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Mechanism of the Cardiotoxic Actions of Terfenadine

1993 • 627 citations

The Pharmacology and Use of H₁-Receptor-Antagonist Drugs

1994 • 326 citations

HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine

1996 • 294 citations

Cardiac Actions of Antihistamines

1996 • 261 citations

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

1993 • 225 citations

Cardiac Electrophysiological Actions of the Histamine H₁-Receptor Antagonists Astemizole and Terfenadine Compared With Chlorpheniramine and Pyrilamine

1995 • 214 citations

Loratadine

1994 • 173 citations

Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin

1988 • 147 citations

Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart.

1993 • 136 citations

Pharmacokinetics and biotransformation studies of terfenadine in man.

1982 • 125 citations

Efficacy and Safety of Fexofenadine Hydrochloride for Treatment of Seasonal Allergic Rhinitis

1997 • 116 citations

Torsade de Pointes with an antihistamine metabolite: Potassium channel blockade with desmethylastemizole

1996 • 94 citations

Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects.

1996 • 75 citations

Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations*

1995 • 71 citations

Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels

1997 • 60 citations

Sedation and Performance Issues in the Treatment of Allergic Conditions

1997 • 55 citations

Interactions of the Nonsedating Antihistamine Loratadine with a Kv1.5-Type Potassium Channel Cloned from Human Heart

1997 • 48 citations

Effect of cetirizine and prednisolone on cellular infiltration and cytokine mRNA expression during allergen‐induced late cutaneous responses

1996 • 38 citations

Effect of Cetirizine on Human Eosinophil Superoxide Generation, Eosinophil Chemotaxis and Eosinophil Peroxidase in vitro

1994 • 33 citations

A comparison of the efficacy of Cetirizine and terfenadine

1993 • 32 citations

Antihistamine activity, central nervous system and cardiovascular profiles of histamine H₁ antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea‐pigs

1995 • 31 citations

Astemizole

1993 • 26 citations

A double‐blind, placebo controlled study of the effect of the specific histamine H1‐receptor antagonist, terfenadine, in chronic severe asthma.

1995 • 25 citations

Lack of effect of loratadine on moderate to severe asthma.

1995 • 21 citations

Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5

1997 • 17 citations

Antiallergic effects of major metabolites of astemizole in rats and guinea pigs.

1991 • 16 citations

Antihistamines in the treatment of asthma

1994 • 11 citations