NF-kB: a pivotal role in asthma and a new target for therapy

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Increased nitric oxide in exhaled air of asthmatic patients

1994 • 1,462 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Induction of nitric oxide synthase in asthma

1993 • 852 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Anti-inflammatory actions of steroids: molecular mechanisms

1993 • 740 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Inhaled Glucocorticoids for Asthma

1995 • 640 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.

1996 • 588 citations

Increase in asthma: a more toxic environment or a more susceptible population?

1994 • 483 citations

Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

1998 • 422 citations

Expression of Inducible Nitric Oxide in Human Lung Epithelial Cells

1994 • 346 citations

Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone

1994 • 311 citations

Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.

1996 • 282 citations

Oxidative Stress Induces NFκB DNA Binding and Inducible NOS mRNA in Human Epithelial Cells

1994 • 263 citations

Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B.

1996 • 252 citations

Cytokines as Mediators of Chronic Asthma

1994 • 194 citations

Mechanisms of Action of Glucocorticoids in Asthma

1996 • 154 citations

Glucocorticoid inhibition of RANTES expression in human lung epithelial cells.

1995 • 134 citations

Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells

1995 • 128 citations

Ozone induction of cytokine‐induced neutrophil chemoattractant (CINC) and nuclear factor‐κb in rat lung: inhibition by corticosteroids

1996 • 102 citations

Spin Trapping Agent, Phenyl N-tertbutyl Nitrone (PBN) Inhibits Induction of Nitric Oxide Synthase in Endotoxin-Induced Shock in Mice

1995 • 87 citations

Characterization of IκB Kinases

1996 • 69 citations

Activation of the transcription factor NF-kappa B in human tracheobronchial epithelial cells by inflammatory stimuli

1995 • 55 citations