Macrophages define the invasive microenvironment in breast cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

2002 • 5,109 citations

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

The Immunobiology of Cancer Immunosurveillance and Immunoediting

2004 • 2,788 citations

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 • 2,597 citations

Distinct Role of Macrophages in Different Tumor Microenvironments

2006 • 2,130 citations

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

2002 • 1,941 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

2001 • 1,584 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

2004 • 1,395 citations

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

2006 • 1,366 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

2005 • 1,266 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

2004 • 1,127 citations

VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells

2006 • 1,122 citations

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

2003 • 1,049 citations

Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer

2006 • 1,020 citations

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

2007 • 1,011 citations

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

2006 • 959 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

Intravital imaging of cell movement in tumours

2003 • 908 citations

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

2008 • 882 citations

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues

2004 • 853 citations

Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression

2005 • 752 citations

Reduced Inflammation in the Tumor Microenvironment Delays the Accumulation of Myeloid-Derived Suppressor Cells and Limits Tumor Progression

2007 • 613 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 597 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 559 citations

Targeting tumor-associated macrophages as a novel strategy against breast cancer

2006 • 539 citations

Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse

1994 • 538 citations

Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)

2005 • 457 citations

Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer

2007 • 437 citations

p50 Nuclear Factor-κB Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor Resistance

2006 • 428 citations

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

2002 • 419 citations

The Adaptive Immunologic Microenvironment in Colorectal Cancer: A Novel Perspective

2007 • 416 citations

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment

2005 • 375 citations

Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density

2005 • 363 citations

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

2003 • 346 citations

Tumor-associated macrophages in breast cancer.

2002 • 346 citations

Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer

2000 • 304 citations

Prognostic Value of Vascular Endothelial Growth Factor in Breast Cancer

2000 • 302 citations

The macrophage growth factor CSF-1 in mammary gland development and tumor progression.

2002 • 279 citations

Colony-Stimulating Factor-1 Blockade by Antisense Oligonucleotides and Small Interfering RNAs Suppresses Growth of Human Mammary Tumor Xenografts in Mice

2004 • 278 citations

Role of infiltrated leucocytes in tumour growth and spread

2004 • 271 citations

Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland

2006 • 261 citations

Tie2-Expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2

2007 • 249 citations

The Inflammatory Tumor Microenvironment and Its Impact on Cancer Development

2006 • 241 citations

Anti-Colony-Stimulating Factor-1 Antibody Staining in Primary Breast Adenocarcinomas Correlates With Marked Inflammatory Cell Infiltrates and Prognosis

1994 • 226 citations

Colony-Stimulating Factor-1 Antibody Reverses Chemoresistance in Human MCF-7 Breast Cancer Xenografts

2006 • 225 citations

Tumor-associated macrophages in neoplastic progression: a paradigm for the in vivo function of chemokines.

1994 • 205 citations

Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development

2002 • 205 citations

Tumor immunoediting and immunosculpting pathways to cancer progression

2007 • 187 citations

Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

2007 • 173 citations

An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations

2005 • 165 citations

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages

2007 • 149 citations

Inflammation and cancer: Breast cancer as a prototype

2007 • 148 citations

Interferon-γ and Cancer Immunoediting

2005 • 136 citations

The collection of the motile population of cells from a living tumor.

2000 • 125 citations

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus.

1994 • 117 citations

Pleiotropic Roles for CSF-1 in Development Defined by the Mouse Mutation Osteopetrotic

1996 • 109 citations

High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer

2008 • 100 citations

M‐CSF (monocyte colony stimulating factor) and M‐CSF receptor expression by breast tumour cells: M‐CSF mediated recruitment of tumour infiltrating monocytes?

1992 • 100 citations

A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis

2007 • 85 citations

Macrophages can recognize and kill tumor cells bearing the membrane isoform of macrophage colony-stimulating factor

1996 • 76 citations

Targeting tumour-associated macrophages

2007 • 59 citations

Tumor infiltrating macrophages reduce development of peritoneal colorectal carcinoma metastases

2008 • 34 citations

Is colony‐stimulating factor‐1 a key mediator of breast cancer invasion and metastasis?

1993 • 34 citations