The Resolution of Relapsing Fever Borreliosis Requires IgM and Is Concurrent with Expansion of B1b Lymphocytes

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Product Differentiation by Analysis of DNA Melting Curves during the Polymerase Chain Reaction

1997 • 1,656 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens

2001 • 955 citations

Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies

1999 • 895 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’

1991 • 723 citations

B-1 and B-2 Cell–Derived Immunoglobulin M Antibodies Are Nonredundant Components of the Protective Response to Influenza Virus Infection

2000 • 572 citations

A Critical Role of Natural Immunoglobulin M in Immediate Defense Against Systemic Bacterial Infection

1998 • 538 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

RU486 (MIFEPRISTONE): Mechanisms of Action and Clinical Uses

1997 • 413 citations

T-Independent Immune Response: New Aspects of B Cell Biology

2000 • 413 citations

B1 cells: similarities and differences with other B cell subsets

2001 • 387 citations

B‐cell subsets and the mature ­preimmune repertoire. Marginal zone and B1 B cells as part of a “natural immune memory”

2000 • 380 citations

Fcα/μ receptor mediates endocytosis of IgM-coated microbes

2000 • 370 citations

The Follicular versus Marginal Zone B Lymphocyte Cell Fate Decision Is Regulated by Aiolos, Btk, and CD21

2001 • 335 citations

Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM

1998 • 321 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

Homeostasis of Peripheral B Cells in the Absence of B Cell Influx from the Bone Marrow

2001 • 313 citations

Differential development of progenitor activity for three B-cell lineages.

1992 • 305 citations

Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7−/− Mice

2001 • 271 citations

B-1 cells: the lineage question revisited

2000 • 243 citations

RELAPSING FEVER

1969 • 215 citations

An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells.

1997 • 207 citations

Antibodies have the intrinsic capacity to destroy antigens

2000 • 198 citations

Rapid and Sensitive Quantification of Borrelia burgdorferi -Infected Mouse Tissues by Continuous Fluorescent Monitoring of PCR

1999 • 188 citations

Natural autoantibodies: from ?horror autotoxicus? to ?gnothi seauton?

1991 • 178 citations

ANTIGENIC VARIATION OF A RELAPSING FEVER BORRELIA SPECIES

1990 • 174 citations

Antigenic Variation in Vector-Borne Pathogens

2000 • 173 citations

Bloodstream- Versus Tick-Associated Variants of a Relapsing Fever Bacterium

1998 • 165 citations

Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues

1994 • 158 citations

The Biology of parasitic spirochetes

1976 • 130 citations

T-Cell-Independent Responses toBorrelia burgdorferiAre Critical for Protective Immunity and Resolution of Lyme Disease

2000 • 124 citations

Selection of an escape variant of Borrelia burgdorferi by use of bactericidal monoclonal antibodies to OspB

1992 • 110 citations

Age-associated increase in expression of the T cell surface markers Thy-1, Lyt-1, and Lyt-2 in congenitally athymic (nu/nu) mice: analysis by flow microfluorometry.

1981 • 100 citations

Cutting Edge: The Spirochetemia of Murine Relapsing Fever Is Cleared by Complement-Independent Bactericidal Antibodies

2001 • 92 citations

Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicatae-mouse model of Lyme disease

1997 • 79 citations

A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein

1994 • 70 citations

In Vitro and In Vivo Neutralization of the Relapsing Fever AgentBorrelia hermsiiwith Serotype-Specific Immunoglobulin M Antibodies

2001 • 68 citations

The Spirochete Borrelia crocidurae Causes Erythrocyte Rosetting during Relapsing Fever

1998 • 59 citations

THE EPIDEMIOLOGY OF THE RELAPSING FEVERS

1976 • 56 citations

T-cell-independent elimination of Borrelia turicatae

1984 • 52 citations

Splenic and Peritoneal B-1 Cells Differ in Terms of Transcriptional and Proliferative Features That Separate Peritoneal B-1 from Splenic B-2 Cells

2001 • 42 citations

Platelet activation by a relapsing fever spirochaete results in enhanced bacterium–platelet interaction via integrin α_IIbβ₃ activation

2001 • 39 citations

Serial Determinations of Platelet Counts in Mice by Flow Cytometry

2001 • 39 citations

Protective activity of Borrelia duttonii-specific immunoglobulin subclasses in mice

1997 • 29 citations

CHARACTERIZATION OF PROTECTIVE ANTIBODIES PRODUCED IN MICE INFECTED WITH BORRELIA DUTTONII

1973 • 26 citations

A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion

1999 • 21 citations

Extrathymic Development of Self-Reactive γδ T Cells in Athymic BALB/cnu/nuMice

1996 • 8 citations