Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Isolation and cultivation of Lyme disease spirochetes.

1984 • 1,554 citations

Detection of Borrelia burgdorferi DNA by Polymerase Chain Reaction in Synovial Fluid from Patients with Lyme Arthritis

1994 • 591 citations

Lyme Borreliosis in Selected Strains and Ages of Laboratory Mice

1990 • 446 citations

Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice.

1991 • 349 citations

Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species.

1993 • 319 citations

Molecular analysis of linear plasmid‐encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi

1989 • 317 citations

Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi

1993 • 294 citations

Genetic variation in the stress response: susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease

1991 • 254 citations

Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.

1989 • 230 citations

Intracellular localization of Borrelia burgdorferi within human endothelial cells

1991 • 183 citations

Polymerase chain reaction primers and probes derived from flagellin gene sequences for specific detection of the agents of Lyme disease and North American relapsing fever

1992 • 171 citations

Lyme Borreliosis in Genetically Resistant and Susceptible Mice with Severe Combined Immunodeficiency

1992 • 170 citations

Balance of synovial fluid IL-1β and IL-1 receptor antagonist and recovery from Lyme arthritis

1993 • 165 citations

Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct.

1991 • 158 citations

Carditis in Lyme Disease Susceptible and Resistant Strains of Laboratory Mice Infected with Borrelia Burgdorferi

1992 • 153 citations

Detection of Borrelia burgdorferi infection in Ixodes dammini ticks with the polymerase chain reaction

1990 • 146 citations

Linear- and circular-plasmid copy numbers in Borrelia burgdorferi

1992 • 135 citations

Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver.

1990 • 125 citations

Target Imbalance: Disparity of Borrelia burgdorferi Genetic Material in Synovial Fluid from Lyme Arthritis Patients

1994 • 119 citations

The relapsing fever agent Borrelia hermsii has multiple copies of its chromosome and linear plasmids.

1992 • 113 citations

Demonstration of Spirochetes in Cardiac Biopsies of Patients with Lyme Disease

1989 • 108 citations

Mode of Inoculation of the Lyme Disease Agent Borrelia burgdorferi Influences Infection and Immune Responses in Inbred Strains of Mice

1993 • 106 citations

Nucleotide sequence of a gene encoding theBorrelia burgdorferiflagellin

1989 • 96 citations

Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice

1992 • 90 citations

Lack of Responsiveness of C3H/HeJ Macrophages to Lipopolysaccharide: The Cellular Basis of LPS-Stimulated Metabolism

1979 • 84 citations

The hamster immune response to tick-transmitted Borrelia burgdorferi differs from the response to needle-inoculated, cultured organisms.

1992 • 82 citations

Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi

1993 • 81 citations

In vitro and in vivo induction of tumor necrosis factor alpha by Borrelia burgdorferi

1992 • 81 citations

Development of a sensitive reverse transcriptase PCR assay, RT-RPCR, utilizing rapid cycle times.

1992 • 72 citations

Demonstration of a B-lymphocyte mitogen produced by the Lyme disease pathogen, Borrelia burgdorferi

1992 • 67 citations

Isolation of interleukin 1 from joint fluids of patients with Lyme disease.

1989 • 51 citations

Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens

1992 • 49 citations

Lyme disease, 1988: Immunologic manifestations and possible immunopathogenetic mechanisms

1989 • 47 citations

In vivo and in vitro evidence of B cell hyperactivity during Lyme disease.

1988 • 40 citations

Murine Lyme borreliosis: route of inoculation determines immune response and infectivity.

1992 • 33 citations

Deleted Work

1955 • 0 citations