Genetics of Longevity and Aging

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

1957 • 4,140 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

2004 • 3,100 citations

Broken Limits to Life Expectancy

2002 • 2,691 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

AN UNSOLVED PROBLEM OF BIOLOGY

1953 • 1,832 citations

Evolution of ageing

1977 • 1,784 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

2002 • 1,506 citations

p53 mutant mice that display early ageing-associated phenotypes

2002 • 1,428 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Mammalian SIRT1 Represses Forkhead Transcription Factors

2004 • 1,352 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Genetic associations with human longevity at the APOE and ACE loci

1994 • 1,079 citations

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

1988 • 958 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

2002 • 849 citations

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

2002 • 842 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

1996 • 813 citations

Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway

2002 • 810 citations

Evolution of ageing

2002 • 800 citations

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

2003 • 782 citations

Regulation of Longevity inCaenorhabditis elegansby Heat Shock Factor and Molecular Chaperones

2003 • 697 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

2003 • 587 citations

Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity

2003 • 571 citations

Modulation of mammalian life span by the short isoform of p53

2004 • 564 citations

Aging and Genome Maintenance: Lessons from the Mouse?

2003 • 556 citations

Premature Aging in Mice Deficient in DNA Repair and Transcription

2002 • 533 citations

Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span

2003 • 504 citations

Cancer and ageing: rival demons?

2003 • 498 citations

Genetics of Aging

1997 • 493 citations

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

2000 • 488 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

2003 • 455 citations

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

2002 • 440 citations

Genetics and the Specificity of the Aging Process

2003 • 439 citations

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

2002 • 431 citations

Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster

2002 • 374 citations

Life-long sustained mortality advantage of siblings of centenarians

2002 • 364 citations

Deletion of Ku86 causes early onset of senescence in mice

1999 • 360 citations

A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4

2001 • 342 citations

Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana)

1993 • 341 citations

Fisher, Medawar, Hamilton and the Evolution of Aging

2000 • 317 citations

Polymorphic Variants of Insulin-Like Growth Factor I (IGF-I) Receptor and Phosphoinositide 3-Kinase Genes Affect IGF-I Plasma Levels and Human Longevity: Cues for an Evolutionarily Conserved Mechanism of Life Span Control

2003 • 309 citations

Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity

2003 • 297 citations

Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

1999 • 280 citations

Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

2002 • 274 citations

Lessons from human progeroid syndromes

2000 • 257 citations

Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

2002 • 247 citations

Inheritance of human longevity in Iceland

2000 • 234 citations

Evolution of lifespan in C. elegans

2000 • 208 citations

Clinical Phenotype of Families with Longevity

2004 • 183 citations

Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease

2002 • 180 citations

Familial Excess Longevity in Utah Genealogies

2001 • 177 citations

Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

2003 • 151 citations

Genetics of Aging in the Fruit Fly,Drosophila melanogaster

2003 • 149 citations

The effects of gene-environment interaction on the expression of longevity

1985 • 148 citations

Testing an ‘aging gene’ in long‐lived Drosophila strains: increased longevity depends on sex and genetic background

2003 • 140 citations

Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase

2001 • 140 citations

Assaying metabolic activity in ageing Caenorhabditis elegans

2002 • 123 citations

Caloric Restriction: A Key to Understanding and Modulating Aging

2013 • 112 citations

The paradox of the insulin/IGF-1 signaling pathway in longevity

2004 • 99 citations

Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse

2002 • 94 citations

Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism

2003 • 91 citations

The Sir2 protein family: A novel deacetylase for gene silencing and more

2000 • 83 citations

The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900

1996 • 83 citations

The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans

2001 • 82 citations

Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

2002 • 76 citations

Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity

2004 • 74 citations

Quantitative trait loci affecting natural variation in Drosophila longevity

2004 • 53 citations

Oxidative stress and aging – the use of superoxide dismutase/catalase mimetics to extend lifespan

2003 • 52 citations

SIR2 and aging – the exception that proves the rule

2001 • 50 citations

Unique lipoprotein phenotype and genotype associated with exceptional longevity

2004 • 43 citations

Caenorhabditis elegans—a paradigm for aging research: advantages and limitations

2002 • 37 citations

Caloric restriction mimetics

2002 • 37 citations

Gene Expression and Regulation in the Extended Longevity Phenotypes of Drosophila

2001 • 28 citations

Molecular Mechanism of Maternal Rescue in the clk-1 Mutants of Caenorhabditis elegans

2003 • 25 citations

Genes that shape the course of ageing

2003 • 23 citations

Functional Genomics of Ageing

2003 • 21 citations

Does Caloric Restriction in the Laboratory Simply Prevent Overfeeding and Return House Mice to Their Natural Level of Food Intake?

2001 • 19 citations