Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

1957 • 4,140 citations

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

1997 • 3,518 citations

Oxidative DNA damage: mechanisms, mutation, and disease

2003 • 3,028 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

2003 • 2,054 citations

Evolution of ageing

1977 • 1,784 citations

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

2002 • 1,506 citations

p53 mutant mice that display early ageing-associated phenotypes

2002 • 1,428 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

The age of cancer

2000 • 949 citations

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

2002 • 849 citations

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

1966 • 831 citations

Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway

2002 • 810 citations

Evolution of ageing

2002 • 800 citations

Does oxidative damage to DNA increase with age?

2001 • 753 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

1994 • 686 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Mechanisms of aging: an appraisal of the oxidative stress hypothesis1,2 1This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Rajindar S. Sohal

2002 • 588 citations

Aging and Genome Maintenance: Lessons from the Mouse?

2003 • 556 citations

Conserved domains in DNA repair proteins and evolution of repair systems

1999 • 551 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

Premature Aging in Mice Deficient in DNA Repair and Transcription

2002 • 533 citations

A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase

1989 • 532 citations

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

2003 • 476 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

2003 • 374 citations

Cancer, aging and cellular senescence.

2000 • 369 citations

Deletion of Ku86 causes early onset of senescence in mice

1999 • 360 citations

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

2001 • 359 citations

A progeroid syndrome in mice is caused by defects in A-type lamins

2003 • 353 citations

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

1998 • 316 citations

Ku complex interacts with and stimulates the Werner protein

2000 • 308 citations

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1998 • 295 citations

Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress

2002 • 295 citations

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1997 • 295 citations

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

2003 • 289 citations

The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

1995 • 279 citations

Handbook of the Biology of Aging

1991 • 259 citations

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

2000 • 243 citations

Somatic mutations and aging: a re-evaluation

2000 • 240 citations

Nucleolar localization of the Werner syndrome protein in human cells

1998 • 210 citations

Evolution of lifespan in C. elegans

2000 • 208 citations

Functional genetic analysis of mouse chromosome 11

2003 • 200 citations

A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy

1998 • 193 citations

Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

2000 • 177 citations

Expression of RANKL and OPG Correlates With Age-Related Bone Loss in Male C57BL/6 Mice

2003 • 161 citations

Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53

2000 • 159 citations

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

2002 • 144 citations

Large genome rearrangements as a primary cause of aging

2002 • 141 citations

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

2003 • 125 citations

The essential role of yeast topoisomerase III in meiosis depends on recombination

1999 • 124 citations

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

2001 • 112 citations

Mice lacking DNA topoisomerase IIIβ develop to maturity but show a reduced mean lifespan

2001 • 107 citations

Effect of dietary restriction on in vivo somatic mutation in mice

1993 • 85 citations

Iron chelation and a free radical scavenger suppress angiotensin II‐induced downregulation of klotho, an anti‐aging gene, in rat

2003 • 76 citations

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

1995 • 73 citations

Frequency of spontaneous chromosome aberrations in mice: effects of age

1999 • 70 citations

Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.

2001 • 67 citations

Immunosenescence phenotypes in the telomerase knockout mouse

2002 • 52 citations

Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice

2001 • 52 citations

Models of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology

2003 • 47 citations

Acceleration of chromosome aberrations in senescence-accelerated strains of mice

1990 • 45 citations

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue

2002 • 40 citations