Engagement of Bone Morphogenetic Protein Type IB Receptor and Smad1 Signaling by Anti-Müllerian Hormone and Its Type II Receptor

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

Characterization of Several Clonal Lines of Cultured Ley dig Tumor Cells: Gonadotropin Receptors and Steroidogenic Responses*

1981 • 596 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Requirement for BMP Signaling in Interdigital Apoptosis and Scale Formation

1996 • 552 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

Nodal signalling in vertebrate development

2000 • 514 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

1997 • 504 citations

The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest

1994 • 486 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb

2000 • 391 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

1994 • 368 citations

Determinants of specificity in TGF-β signal transduction

1998 • 364 citations

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

1996 • 354 citations

Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

1996 • 336 citations

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

1995 • 326 citations

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct

1994 • 290 citations

Cloning, expression, and alternative splicing of the receptor for anti-Müllerian hormone.

1994 • 279 citations

The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

1996 • 275 citations

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors

1998 • 265 citations

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

1997 • 260 citations

The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo

1999 • 252 citations

Receptors for anti-Müllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation

1998 • 248 citations

Insensitivity to anti–Müllerian hormone due to a mutation in the human anti–Müllerian hormone receptor

1995 • 228 citations

Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity

2000 • 223 citations

Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-β Family Receptors

1999 • 219 citations

A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity

1997 • 203 citations

Anti-Müllerian hormone produces endocrine sex reversal of fetal ovaries.

1989 • 202 citations

Effect of Anti-Mullerian Hormone on Sertoli and Leydig Cell Functions in Fetal and Immature Rats¹

1998 • 147 citations

Persistence of m�llerian derivatives in males

1999 • 118 citations

Müllerian-Inhibiting Substance Regulates Androgen Synthesis at the Transcriptional Level1

1999 • 103 citations

The inhibitory effects of müllerian-inhibiting substance on epidermal growth factor induced proliferation and progesterone production of human granulosa-luteal cells.

1992 • 100 citations

Müllerian-Inhibiting Substance Type II Receptor Expression and Function in Purified Rat Leydig Cells*

1999 • 80 citations

Clinical aspects and molecular genetics of the persistent Müllerian duct syndrome

1997 • 68 citations

Paracrine-Mediated Apoptosis in Reproductive Tract Development

1999 • 62 citations

A mouse Sertoli cell line expressing anti-Müllerian hormone and its type II receptor

1997 • 57 citations

Mutant Isoforms of the Anti-Müllerian Hormone Type II Receptor Are Not Expressed at the Cell Membrane

1996 • 51 citations

Experimental Induction ofBMP-4Expression Leads to Apoptosis in the Paraxial and Lateral Plate Mesoderm

1998 • 38 citations

A chimeric serine/threonine kinase receptor system reveals the potential of multiple type II receptors to cooperate with transforming growth factor-beta type I receptor.

1997 • 17 citations