Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: A link to the sex determination cascade

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

1990 • 3,134 citations

Male development of chromosomally female mice transgenic for Sry

1991 • 2,157 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

1990 • 1,630 citations

A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation

1994 • 1,604 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells

1986 • 997 citations

Expression of a candidate sex-determining gene during mouse testis differentiation

1990 • 834 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.

1992 • 635 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases.

1994 • 589 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Studies on Sex Differentiation in Mammals

1973 • 558 citations

A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.

1992 • 536 citations

Expression of the mouse anti-Müllerian hormone gene suggests a role in both male and female sexual differentiation

1991 • 458 citations

DNA Binding Activity of Recombinant SRY from Normal Males and XY Females

1992 • 454 citations

Mutation of the POU-Specific Domain of Pit-1 and Hypopituitarism Without Pituitary Hypoplasia

1992 • 451 citations

Abnormal sexual development in transgenic mice chronically expressing Müllerian inhibiting substance

1990 • 434 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.

1993 • 411 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.

1993 • 380 citations

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I

1992 • 375 citations

A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development.

1993 • 365 citations

A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.

1992 • 302 citations

Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases

1994 • 301 citations

Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.

1993 • 262 citations

An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.

1992 • 260 citations

Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.

1993 • 255 citations

A Shared Promoter Element Regulates the Expression of Three Steridogenic Enzymes

1991 • 211 citations

Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP.

1993 • 209 citations

DNA-binding properties of the product of the testis-determining gene and a related protein

1991 • 200 citations

The Orphan Receptor Rev-ErbAα Activates Transcription via a Novel Response element

1993 • 199 citations

Proteolytic processing of mullerian inhibiting substance produces a transforming growth factor-beta-like fragment.

1988 • 190 citations

Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression

1993 • 154 citations

SRY recognizes conserved DNA sites in sex-specific promoters.

1993 • 151 citations

Transcription of the sex-determining region genes Sry and Zfy in the mouse preimplantation embryo.

1993 • 137 citations

Anti-Müllerian hormone Bruxelles: a nonsense mutation associated with the persistent Müllerian duct syndrome.

1991 • 132 citations

Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily.

1992 • 130 citations

Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily.

1993 • 119 citations

The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.

1993 • 117 citations

Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors.

1994 • 116 citations

cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3',5'-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells.

1993 • 114 citations

Human P450scc Gene Transcription Is Induced by Cyclic AMP and Repressed by 12-O-Tetradecanoylphorbol-13-Acetate and A23187 through Independent cis Elements

1990 • 109 citations

Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues

1993 • 109 citations

Directed expression of an oncogene to Sertoli cells in transgenic mice using mullerian inhibiting substance regulatory sequences.

1992 • 102 citations

Mullerian-Inhibiting Substance

1990 • 93 citations

Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP

1993 • 87 citations

Familial case with sequence variant in the testis-determining region associated with two sex phenotypes.

1992 • 84 citations

Ovary? Testis?—A mammalian dilemma

1994 • 63 citations

Expression of the gene for anti-Mullerian hormone

1990 • 63 citations

Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements.

1990 • 62 citations

Isolation of the rat gene for Mullerian inhibiting substance

1992 • 60 citations

Anti-Müllerian hormone and intersex states

1991 • 52 citations

cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3',5'-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells

1993 • 48 citations

Directed expression of an oncogene to Sertoli cells in transgenic mice using mullerian inhibiting substance regulatory sequences

1992 • 41 citations

Identification of a core motif that is recognized by three members of the HMG class of transcriptional regulators: IRE‐ABP, SRY, and TCF‐1α

1992 • 36 citations

Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily

1993 • 36 citations

Developmentally regulated polyadenylation of two discrete messenger ribonucleic acids for müllerian inhibiting substance.

1992 • 22 citations

Sex determination and gonadogenesis: a transcription cascade of sex chromosome and autosome genes.

1992 • 9 citations

Developmentally regulated polyadenylation of two discrete messenger ribonucleic acids for mullerian inhibiting substance

1992 • 6 citations