Serine/threonine kinase receptors and ligands

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Growth differentiation factor-9 is required during early ovarian folliculogenesis

1996 • 1,618 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Renal and neuronal abnormalities in mice lacking GDNF

1996 • 1,260 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Defects in enteric innervation and kidney development in mice lacking GDNF

1996 • 1,169 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Müllerian-inhibiting substance function during mammalian sexual development

1994 • 661 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

1996 • 370 citations

Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.

1995 • 368 citations

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

1996 • 354 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise

1997 • 348 citations

Activation of Signalling by the Activin Receptor Complex

1996 • 317 citations

Mad-related genes in the human

1996 • 308 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

Insensitivity to anti–Müllerian hormone due to a mutation in the human anti–Müllerian hormone receptor

1995 • 228 citations

Bone morphogenetic protein receptors

1996 • 223 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor

1995 • 196 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

A 27 base-pair deletion of the anti-mullerian type II receptor gene is the most common cause of the persistent mullerian duct syndrome

1996 • 153 citations

De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease

1996 • 143 citations

Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos

1996 • 143 citations

Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice.

1996 • 141 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease.

1996 • 128 citations

The p21 ^RAS Farnesyltransferase α Subunit in TGF-β and Activin Signaling

1996 • 128 citations

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.

1993 • 122 citations

Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

1996 • 120 citations

Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice.

1996 • 118 citations

A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation

1996 • 111 citations

Cloning and Expression of the Chick Anti-Müllerian Hormone Gene

1996 • 103 citations

Formation and activation by phosphorylation of activin receptor complexes.

1996 • 97 citations

An activated form of type I serine/threonine kinase receptor TARAM-A reveals a specific signalling pathway involved in fish head organiser formation

1996 • 89 citations

Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human

1996 • 89 citations

Activin signaling through activin receptor type II causes the cachexia- like symptoms in inhibin-deficient mice

1996 • 73 citations

Synergistic effects of inhibins and müllerian-inhibiting substance on testicular tumorigenesis.

1995 • 73 citations

Formation and activation by phosphorylation of activin receptor complexes

1996 • 54 citations

Inactive Type II and Type I Receptors for TGFβ Are Dominant Inhibitors of TGFβ-dependent Transcription

1995 • 54 citations

The GS Domain of the Transforming Growth Factor-β Type-I Receptor Is Important in Signal Transduction

1995 • 53 citations

Mutant Isoforms of the Anti-Müllerian Hormone Type II Receptor Are Not Expressed at the Cell Membrane

1996 • 51 citations

Transforming Growth Factor-β Signal Transduction

1996 • 38 citations

Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice

1996 • 37 citations

Roads to neuralness: Embryonic neural induction as derepression of a default state

1994 • 36 citations

Synergistic effects of inhibins and mullerian-inhibiting substance on testicular tumorigenesis

1995 • 32 citations

Truncated Activin Type II Receptors Inhibit Activin Bioactivity by the Formation of Heteromeric Complexes with Activin Type I Receptors

1996 • 25 citations

Molecular cloning of an avian anti-Müllerian hormone homologue

1996 • 25 citations

Ligand-Induced Recruitment and Phosphorylation of Reduced TGF-β Type I Receptor

1995 • 16 citations