The Role Of Caveolin-1 In Androgen Insensitive Prostate Cancer
Data up to Jan 2025
Total Citations Per Year
Abstract
References (85)
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 • 5,334 citations
Cancer Statistics, 2001
2001 • 3,342 citations
Pathologic and Clinical Findings to Predict Tumor Extent of Nonpalpable (Stage T1 c) Prostate Cancer
1994 • 1,764 citations
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
2001 • 1,517 citations
Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.
1990 • 1,147 citations
Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
2001 • 1,144 citations
Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.
1992 • 1,063 citations
A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
1999 • 983 citations
Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.
1994 • 940 citations
Urologic pathology: The prostate
1977 • 821 citations
The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression
1996 • 739 citations
A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth
1998 • 720 citations
Cancer Surveillance Series: Interpreting Trends in Prostate Cancer Part I: Evidence of the Effects of Screening in Recent Prostate Cancer Incidence, Mortality, and Survival Rates
1999 • 662 citations
Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor
2001 • 638 citations
Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy
1998 • 590 citations
From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
1999 • 587 citations
Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
1998 • 435 citations
Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression
2000 • 381 citations
Recombinant Expression of Caveolin-1 in Oncogenically Transformed Cells Abrogates Anchorage-independent Growth
1997 • 377 citations
Ligand-independent activation of steroid hormone receptors
1998 • 349 citations
Elevated expression of caveolin is associated with prostate and breast cancer.
1998 • 336 citations
Comprehensive Textbook of Genitourinary Oncology
2012 • 325 citations
Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae
2002 • 318 citations
Genetic Alterations in Hormone-Refractory Recurrent Prostate Carcinomas
1998 • 314 citations
Regulation of prostatic growth and function by peptide growth factors
1996 • 313 citations
Randomized Prospective Study Comparing Radical Prostatectomy Alone Versus Radical Prostatectomy Preceded by Androgen Blockage in Clinical Stage B2 (T2bNxM0) Prostate Cancer
1995 • 310 citations
Up-regulation of Caveolae and Caveolar Constituents in Multidrug-resistant Cancer Cells
1998 • 298 citations
Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker.
1999 • 291 citations
Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity.
2000 • 281 citations
Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes.
1998 • 274 citations
Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1Arrest via a p53/p21WAF1/Cip1-dependent Mechanism
2001 • 267 citations
Critical factors in the biology of human cancer metastasis.
1995 • 266 citations
Role of PI3K Signaling in Survival and Progression of LNCaP Prostate Cancer Cells to the Androgen Refractory State
2001 • 251 citations
Cancer Surveillance Series: Interpreting Trends in Prostate Cancer Part II: Cause of Death Misclassification and the Recent Rise and Fall in Prostate Cancer Mortality
1999 • 249 citations
Caveolin-1 Interacts with Androgen Receptor
2001 • 239 citations
Can Radical Prostatectomy Alter the Progression of Poorly Differentiated Prostate Cancer?
1994 • 234 citations
Caveolin-3 in muscular dystrophy
1998 • 230 citations
Overexpression of caveolin‐1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
2002 • 229 citations
Genes encoding human caveolin‐1 and ‐2 are co‐localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers
1998 • 227 citations
Invasion activating caveolin-1 mutation in human scirrhous breast cancers.
2001 • 225 citations
Chromosomal anomalies in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization.
1995 • 225 citations
Cancer Surveillance Series: Interpreting Trends in Prostate Cancer Part III: Quantifying the Link Between Population Prostate-Specific Antigen Testing and Recent Declines in Prostate Cancer Mortality
1999 • 222 citations
Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer.
2001 • 221 citations
Comprehensive Textbook of Genitourinary Oncology
1997 • 214 citations
Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells.
2001 • 193 citations
Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria
2001 • 193 citations
Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells
1998 • 186 citations
Radical prostatectomy for adenocarcinoma of the prostate: The influence of preoperative and pathologic findings on biochemical disease-free outcome
1994 • 173 citations
Allelic loss in locally metastatic, multisampled prostate cancer.
1994 • 170 citations
Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival.
1996 • 167 citations
HER-2/neu (p185neu) protein expression in the natural or treated history of prostate cancer.
2001 • 161 citations
Upregulation of caveolin‐1 and caveolae organelles in Taxol‐resistant A549 cells
1998 • 154 citations
Caveolin-1 Potentiates Estrogen Receptor α (ERα) Signaling
1999 • 151 citations
Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis
2000 • 132 citations
Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling
2001 • 125 citations
Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines
1999 • 124 citations
Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC.
2001 • 123 citations
Hypermethylation of the caveolin‐1 gene promoter in prostate cancer
2001 • 122 citations
Caveolin-I, a putative tumour suppressor gene
2001 • 118 citations
Identification of caveolin-1 in lipoprotein particles secreted by exocrine cells
1999 • 117 citations
Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.
1995 • 114 citations
Caveolin-1 expression is associated with high-grade bladder cancer
2001 • 112 citations
Expression level of Bcl-2 determines anti- or proapoptotic function.
1999 • 109 citations
Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells.
1999 • 109 citations
The expression of drug resistance gene products during the progression of human prostate cancer.
1998 • 108 citations
Isolated endosomes from quiescent rat liver contain the signal transduction machinery
1998 • 104 citations
Hypermethylation of the caveolin-1 gene promoter in prostate cancer
2001 • 98 citations
The indications, rationale, and results of neoadjuvant androgen deprivation in the treatment of prostatic cancer: Memorial Sloan-Kettering Cancer Center results
1997 • 90 citations
Natural History of Low-Stage Prostatic Cancer and the Impact of Early Detection
1990 • 82 citations
Review of allelic loss and gain in prostate cancer
1996 • 73 citations
Abrogation of c-Raf expression induces apoptosis in tumor cells
1998 • 69 citations
Prostate Cancer : Biology, Genetics, and the New Therapeutics
2007 • 61 citations
Prostate cancer: biology, genetics, and the new therapeutics
2002 • 59 citations
Accomplishments in cancer research, 1984
1987 • 57 citations
Elevated caveolin-1 levels in African-American versus white-American prostate cancer.
2000 • 56 citations
HER2 in Prostate Cancer--a Viable Target or Innocent Bystander?
2000 • 42 citations
PSA levels and the rate of positive surgical margins in radical prostatectomy specimens preceded by androgen blockade in clinical B2 (T2bNxMo) prostate cancer
1997 • 37 citations
Dietary 4-HPR suppresses the development of bone metastasis in vivo in a mouse model of prostate cancer progression.
2000 • 31 citations
Combined androgen blockade: the gold standard for metastatic prostate cancer.
1997 • 28 citations
Spontaneous but not experimental metastatic activities differentiate primary tumor-derived vs metastasis-derived mouse prostate cancer cell lines.
1997 • 23 citations
In situ gene therapy for prostate cancer: immunomodulatory approaches
2001 • 17 citations
A Prospective Randomized Trial for Treating Stages B2 and C Prostate Cancer: Radical Surgery or Irradiation with Neoadjuvant Endocrine Therapy
1994 • 11 citations
Prostate Cancer: Numbers May Not Tell the Whole Story
2000 • 9 citations
Caveolin-1: a complex and provocative therapeutic target in prostate cancer and potentially other malignancies
1999 • 6 citations
Molecular Pathways Underlying Prostate Cancer Progression: The Role of Caveolin-1
2003 • 1 citations