Diffusible factors in vertebrate embryonic induction

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Molecular modeling of protein-glycosaminoglycan interactions.

1989 • 1,288 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Embryonic Development and Induction

1939 • 1,175 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 • 747 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

Transforming growth factor α

1988 • 707 citations

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

1991 • 698 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

A new retinoic acid receptor identified from a hepatocellular carcinoma

1988 • 613 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

1990 • 587 citations

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

1991 • 587 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor

1989 • 557 citations

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

1989 • 518 citations

Steel locus defines new multipotent growth factor

1990 • 509 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

1989 • 482 citations

Neuropoietic cytokines in the hematopoietic fold

1991 • 474 citations

The formation of the mesoderm in urodelean amphibians

1969 • 472 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Mesoderm Induction in Amphibians: the Role of TGF-β2-Like Factors

1988 • 452 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

Effects of the steel gene product on mouse primordial germ cells in culture

1991 • 405 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Embryonic induction - molecular prospects

1987 • 381 citations

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis

1991 • 373 citations

Variations of cervical vertebrate after expression of a Hox-1.1 transgene in mice

1990 • 371 citations

The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer

1988 • 367 citations

Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis.

1990 • 364 citations

Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor)

1990 • 357 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

The neural crest cell lineage problem: Neuropoiesis?

1989 • 315 citations

A new approach to the development of the cerebellum provided by the quail–chick marker system

1990 • 305 citations

Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

1990 • 304 citations

Proliferation and differentiation of embryonic chick sympathetic neurons: Effects of ciliary neurotrophic factor

1989 • 297 citations

The “Organization Center” of the Amphibian Embryo: Its Origin, Spatial Organization, and Morphogenetic Action

1973 • 296 citations

Inductive Processes in Embryonic Development

1966 • 287 citations

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

1990 • 280 citations

Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.

1991 • 279 citations

Subunit promiscuity among hemopoietic growth factor receptors

1991 • 273 citations

Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage

1990 • 271 citations

Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

1989 • 264 citations

Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud

1990 • 252 citations

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats

1989 • 252 citations

Retinoids and vertebrate limb pattern formation

1989 • 251 citations

Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes

1988 • 249 citations

Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos.

1991 • 247 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

Retinoids, homeobox genes, and limb morphogenesis

1989 • 242 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

Spatial distribution of cellular protein binding to retinoic acid in the chick limb bud

1988 • 241 citations

Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development

1991 • 223 citations

Target regulation of neurotransmitter phenotype

1990 • 221 citations

Retinoic acid modifies mesodermal patterning in early Xenopus embryos.

1991 • 221 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.

1990 • 213 citations

Generation of sensory neurons is stimulated by leukemia inhibitory factor.

1991 • 208 citations

Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos

1991 • 204 citations

Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid.

1990 • 199 citations

Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin

1991 • 194 citations

Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo

1990 • 184 citations

The int-2 proto-oncogene is responsible for induction of the inner ear

1991 • 181 citations

Retinoic acid perturbs the expression of Xhox.lab genes and alters mesodermal determination in Xenopus laevis.

1991 • 163 citations

The DVR gene family in embryonic development

1991 • 159 citations

Genital ridges exert long-range effects on mouse primordial germ cell numbers and direction of migration in culture

1990 • 158 citations

Extracellular matrix-associated molecules collaborate with ciliary neurotrophic factor to induce type-2 astrocyte development.

1990 • 155 citations

Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF

1989 • 154 citations

Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.

1991 • 151 citations

Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation.

1988 • 147 citations

PDGF and intracellular signaling in the timing of oligodendrocyte differentiation.

1989 • 146 citations

Differentiation signals in the CNS: Type-2 astrocyte development in vitro as a model system

1990 • 139 citations

A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.

1991 • 131 citations

Temporal and regional differences in the expression pattern of distinct retinoic acid receptor-β transcripts in the chick embryo

1991 • 131 citations

Effect of Wnt-1 and Related Proteins on Gap Junctional Communication in Xenopus Embryos

1991 • 129 citations

Recombinant Cholinergic Differentiation Factor (Leukemia Inhibitory Factor) Regulates Sympathetic Neuron Phenotype by Alterations in the Size and Amounts of Neuropeptide mRNAs

1991 • 123 citations

Control of cell fate in a vertebrate neurogenic lineage

1990 • 120 citations

Separation and partial characterization of neuropeptide-inducing factors in heart cell conditioned medium

1990 • 117 citations

Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

1989 • 112 citations

Characterization of concentration gradients of a morphogenetically active retinoid in the chick limb bud.

1987 • 109 citations

The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences.

1985 • 106 citations

A retinoic acid receptor expressed in the early development of Xenopus laevis.

1991 • 106 citations

Structure elucidation of two differentiation inducing factors (DIF-2 and DIF-3) from the cellular slime mould Dictyostelium discoideum

1988 • 99 citations

Analysis of competence: receptors for fibroblast growth factor in early Xenopus embryos

1989 • 97 citations

Retinoic acid can mimic endogenous signals involved in transformation of the xenopus nervous system

1991 • 92 citations

All components required for the eventual activation of muscle-specific actin genes are localized in the subequatorial region of an uncleaved amphibian egg.

1985 • 91 citations

Spatial aspects of neural induction in Xenopus laevis

1989 • 91 citations

Characterization of a target-derived neuronal cholinergic differentiation factor

1990 • 89 citations

Growth factors as morphogens: do gradients and thresholds establish body plan?

1991 • 86 citations

Localization of cholinergic differentiation factor/leukemia inhibitory factor mRNA in the rat brain and peripheral tissues.

1991 • 83 citations

Expression of Epi 1, an epidermis-specific marker in Xenopus laevis embryos, is specified prior to gastrulation

1988 • 77 citations

Retinoic acid and chick limb bud development

1991 • 74 citations

Embryonic Development and Induction

1939 • 70 citations

The nature of the mesoderm-inducing signal in Xenopus: a transfilter induction study

1991 • 52 citations

Antagonism of tolazoline by histamine H2-receptor blockers

1975 • 46 citations

Vitamin A and the control of pattern in developing limbs.

1983 • 42 citations

The role of fibroblast growth factor in early Xenopus development

1989 • 37 citations

The DIF-1 signaling system in Dictyostelium. Metabolism of the signal.

1991 • 27 citations

The Successive Steps in the Pattern Formation of the Amphibian Central Nervous System

1991 • 19 citations

Induction and the Organization of the Body Plan in Xenopus Development

2007 • 7 citations