A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

1982 • 764 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

1989 • 499 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence

1990 • 373 citations

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

1983 • 352 citations

Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis.

1983 • 293 citations

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact

1984 • 222 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains

1988 • 178 citations

The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.

1985 • 143 citations

Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.

1988 • 139 citations

The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences.

1985 • 106 citations

Differential Processing of Colony-Stimulating Factor 1 Precursors Encoded by Two Human cDNAs

1988 • 103 citations

In Vivo Identification of the Transforming Gene Product of Simian Sarcoma Virus

1982 • 100 citations

Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer.

1988 • 96 citations

Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules.

1987 • 85 citations

Ultrastructural localization of a platelet-derived growth factor/v-sis-related protein(s) in cytoplasm and nucleus of simian sarcoma virus-transformed cells.

1987 • 63 citations

Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B

1990 • 60 citations

In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product.

1985 • 54 citations

Detection of PDGF-2 homodimers in human tumor cells.

1987 • 47 citations