Flavopiridol Inhibits P-TEFb and Blocks HIV-1 Replication

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

1998 • 1,213 citations

NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation

1999 • 797 citations

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

1998 • 792 citations

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

1997 • 692 citations

P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II

2000 • 671 citations

Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase

1996 • 645 citations

Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation

1995 • 544 citations

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1997 • 539 citations

Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

1996 • 535 citations

Identification of multiple cyclin subunits of human P-TEFb

1998 • 512 citations

Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

2000 • 501 citations

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1996 • 477 citations

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

1998 • 428 citations

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

1998 • 408 citations

Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275

1994 • 349 citations

Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription invitro

1998 • 343 citations

HIV-1 Tat protein promotes formation of more-processive elongation complexes.

1991 • 295 citations

Control of formation of two distinct classes of RNA polymerase II elongation complexes.

1992 • 295 citations

Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol.

1999 • 255 citations

RNA Polymerase II Elongation Control

1998 • 238 citations

Cyclin K Functions as a CDK9 Regulatory Subunit and Participates in RNA Polymerase II Transcription

1999 • 221 citations

A protein phosphatase functions to recycle RNA polymerase II

1999 • 195 citations

Upregulation of cyclin T1/CDK9 complexes during T cell activation

1998 • 130 citations

Tat Transactivation: A Model for the Regulation of Eukaryotic Transcriptional Elongation

1999 • 128 citations

HIV-1 Tat: coping with negative elongation factors

1999 • 109 citations

Association of Human Immunodeficiency Virus Nef Protein with Actin is Myristoylation Dependent and Influences its Subcellular Localization

1997 • 84 citations

Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication

1999 • 71 citations

Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 tat-activation

1998 • 67 citations

Regulation of Carboxyl-terminal Domain Phosphatase by HIV-1 Tat Protein

1998 • 48 citations

Highly Divergent Lentiviral Tat Proteins Activate Viral Gene Expression by a Common Mechanism

1999 • 40 citations