Cell-mediated cytotoxic mechanisms

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Apoptosis

1993 • 972 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

1993 • 541 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

1993 • 341 citations

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

1992 • 282 citations

Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.

1993 • 226 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.

1993 • 137 citations

Mechanisms of immune lysis. III. Characterization of the nature and kinetics of the cytotoxic T lymphocyte-induced nuclear lesion in the target.

1982 • 113 citations

Cell-mediated cytotoxicity

1993 • 108 citations

Role of TNF-alpha in CD8+ cytotoxic T lymphocyte-mediated lysis.

1993 • 102 citations

Proteases and lymphocyte cytotoxic killing mechanisms

1993 • 72 citations

Cell-mediated cytotoxicity: contact and secreted factors

1993 • 69 citations

A role for calcineurin in degranulation of murine cytotoxic T lymphocytes.

1993 • 47 citations

Peptide epitope induced apoptosis of human cytotoxic T lymphocytes. Implications for peripheral T cell deletion and peptide vaccination.

1993 • 41 citations

Expression of lymphocyte perforin in the mouse uterus during pregnancy

1991 • 36 citations

Limited specific T-cell mediated cytolysis in the absence of extracellular Ca2+.

1980 • 36 citations

Mechanism of lymphocyte-mediated cytolysis: functional cytolytic T cells lacking perforin and granzymes.

1993 • 34 citations

Transfection of mouse cytotoxic T lymphocyte with an antisense granzyme A vector reduces lytic activity.

1992 • 33 citations

Peritoneal exudate lymphocyte and mixed lymphocyte culture hybridomas are cytolytic in the absence of cytotoxic cell proteinases and perforin

1992 • 33 citations

Cytotoxicity by tumor necrosis factor is mediated by both p55 and p70 receptors

1993 • 28 citations

Charge‐dependent binding of granzyme A (MTSP‐1) to basement membranes

1993 • 25 citations

Bystander apoptosis induced by CD8⁺ cytotoxic T cell (CTL) clones: implications for CTL lytic mechanisms

1993 • 24 citations

Human CD4+ cytolytic T cells kill antigen-pulsed target T cells by induction of apoptosis.

1993 • 24 citations

Mechanisms of cytotoxicity used by human peripheral blood CD4+ and CD8+ T cell subsets. The role of granule exocytosis.

1993 • 22 citations

Cytolytic activity of murine CD4+ T cell clones correlates with IFN-gamma production in mouse strains having a BALB/c background.

1993 • 19 citations

Detachment and Lysis of Adherent Target Cells by CD4+ T Cell Clones Involve Multiple Effector Mechanisms

1993 • 11 citations

Cytolytic T cells keep their secrets

1993 • 5 citations

Peptide Epitope-Induced Apoptosis Of Human Cytotoxic T Lymphocytes

2024 • 1 citations