Sildenafil Inhibits β-Adrenergic–Stimulated Cardiac Contractility in Humans

Clinical Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Left Ventricular Filling Pressures

2000 • 2,755 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Treatment of Pulmonary Arterial Hypertension

2004 • 1,673 citations

Assessment of Mitral Annulus Velocity by Doppler Tissue Imaging in the Evaluation of Left Ventricular Diastolic Function

1997 • 1,573 citations

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

2005 • 886 citations

Pulsed Doppler echocardiographic determination of stroke volume and cardiac output: clinical validation of two new methods using the apical window.

1984 • 729 citations

Nitric Oxide and Cardiac Function

2003 • 554 citations

Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

1999 • 536 citations

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1999 • 522 citations

Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension

2003 • 381 citations

Effects of sildenafil citrate on human hemodynamics

1999 • 369 citations

Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure

2000 • 306 citations

Hemodynamic Effects of Sildenafil in Men with Severe Coronary Artery Disease

2000 • 286 citations

Regulation of Gene Expression by Cyclic GMP

2003 • 276 citations

Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System

2003 • 264 citations

Sildenafil Induces Delayed Preconditioning Through Inducible Nitric Oxide Synthase–Dependent Pathway in Mouse Heart

2003 • 240 citations

Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure

2001 • 228 citations

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase

1998 • 221 citations

Nitric Oxide Inhibits the Positive Inotropic Response to β-Adrenergic Stimulation in Humans With Left Ventricular Dysfunction

1995 • 218 citations

cGMP Catabolism by Phosphodiesterase 5A Regulates Cardiac Adrenergic Stimulation by NOS3-Dependent Mechanism

2004 • 211 citations

HEMODYNAMIC EFFECTS OF SILDENAFIL IN MEN WITH SEVERE CORONARY ARTERY DISEASE

2000 • 197 citations

Cardiovascular Effects of Sildenafil During Exercise in Men With Known or Probable Coronary Artery Disease

2002 • 185 citations

Sildenafil Effects on Exercise, Neurohormonal Activation, and Erectile Dysfunction in Congestive Heart Failure

2002 • 182 citations

Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice

2003 • 160 citations

Therapeutic Potential of Phosphodiesterase 5 Inhibition for Cardiovascular Disease

2003 • 154 citations

The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease

2002 • 144 citations

Effects of acute beta-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise.

1994 • 128 citations

Sympathetic Activation by Sildenafil

2000 • 123 citations

cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.

1997 • 121 citations

Prognostic Value of Noninvasively Obtained Left Ventricular Contractile Reserve in Patients With Severe Heart Failure

1997 • 104 citations

Ventricular systolic assessment in patients with dilated cardiomyopathy by preload-adjusted maximal power. Validation and noninvasive application.

1994 • 83 citations

PDE5 Inhibitor Sildenafil Citrate Augments Endothelium-Dependent Vasodilation in Smokers

2003 • 69 citations

Sildenafil citrate does not affect cardiac contractility in human or dog heart

2003 • 64 citations

Sildenafil: Emerging Cardiovascular Indications

2004 • 58 citations

Cyclic Nucleotide Phosphodiesterase Type 5 Activity Limits Blood Flow to Hypoperfused Myocardium During Exercise

2000 • 52 citations

Effects of sildenafil citrate (viagra) on cardiac repolarization and on autonomic control in subjects with chronic heart failure

2002 • 51 citations

Effects of Sildenafil (Viagra) on Human Myocardial Contractility, In Vitro Arrhythmias, and Tension of Internal Mammaria Arteries and Saphenous Veins

2003 • 43 citations

Dobutamine pharmacokinetics during dobutamine stress echocardiography

1997 • 33 citations

Interaction of Sildenafil With cAMP-Mediated Vasodilation In Vivo

2002 • 30 citations

Optimal preload adjustment of maximal ventricular power index varies with cardiac chamber size

1998 • 30 citations