Effects of Sildenafil (Viagra) on Human Myocardial Contractility, In Vitro Arrhythmias, and Tension of Internal Mammaria Arteries and Saphenous Veins

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

1991 • 2,186 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

INCIDENCE OF ERECTILE DYSFUNCTION IN MEN 40 TO 69 YEARS OLD: LONGITUDINAL RESULTS FROM THE MASSACHUSETTS MALE AGING STUDY

2000 • 1,135 citations

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

1996 • 1,070 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 759 citations

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1999 • 522 citations

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

1987 • 500 citations

Use of sildenafil (Viagra) in patients with cardiovascular disease

1999 • 452 citations

Nitric oxide attenuates cardiac myocyte contraction

1993 • 405 citations

Effect of Inhaled Iloprost Plus Oral Sildenafil in Patients With Primary Pulmonary Hypertension

2001 • 402 citations

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1999 • 397 citations

Effects of sildenafil citrate on human hemodynamics

1999 • 369 citations

Sildenafil citrate and blood-pressure–lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist

1999 • 339 citations

Overall cardiovascular profile of sildenafil citrate

1999 • 313 citations

Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure

2000 • 306 citations

Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of mechanoelectrical feedback.

1990 • 276 citations

Activation of Distinct cAMP-Dependent and cGMP-Dependent Pathways by Nitric Oxide in Cardiac Myocytes

1999 • 273 citations

Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure

2001 • 228 citations

Heart Rate, Rate-Pressure Product, and Oxygen Uptake During Four Sexual Activities

1984 • 184 citations

Dose-dependent inhibition of stretch-induced arrhythmias by gadolinium in isolated canine ventricles. Evidence for a unique mode of antiarrhythmic action.

1991 • 180 citations

Cardiovascular events in users of sildenafil: results from first phase of prescription event monitoring in England

2001 • 135 citations

Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue

2000 • 134 citations

Expression, structure and chromosomal localization of the human cGMP‐binding cGMP‐specific phosphodiesterase PDE5A gene

1998 • 113 citations

Acute effects of nitric oxide and cyclic GMP on human myocardial contractility.

1997 • 98 citations

Myocardial ischemia during sexual activity in patients with coronary artery disease

1995 • 98 citations

Sildenafil (Viagra) Prolongs Cardiac Repolarization by Blocking the Rapid Component of the Delayed Rectifier Potassium Current

2000 • 97 citations

The biochemical and neurologic basis for the treatment of male erectile dysfunction.

2001 • 93 citations

Alterations of β-adrenoceptor-G-protein-regulated adenylyl cyclase in heart failure

1995 • 78 citations

Alterations of ?-adrenoceptor-G-protein-regulated adenylyl cyclase in heart failure

1995 • 66 citations

Novel Alternative Splice Variants of cGMP-binding cGMP-specific Phosphodiesterase

1998 • 65 citations

Heart rate, rate-pressure product, and oxygen uptake during four sexual activities

1984 • 38 citations

Effects of sildenafil on cardiac repolarization

2002 • 36 citations

Screening of positive inotropic agents in isolated cardiac preparations from different sources

1989 • 32 citations

Current Status of Phosphodiesterase Inhibitors in the Treatment of Congestive Heart Failure

1992 • 30 citations

Enhancement of the effectiveness of milrinone to increase force of contraction by stimulation of cardiac beta-adrenoceptors in the failing human heart

1988 • 28 citations

Concentration-response curves of positive inotropic agents before and after ouabain pretreatment

1985 • 24 citations

Triggered propagated contractions in human atrial trabeculae

1993 • 19 citations

Erectile dysfunction: causes, diagnosis, and treatment.

1989 • 15 citations

Intravenous milrinone: Therapeutic responses in heart failure

1991 • 8 citations