Sildenafil: Emerging Cardiovascular Indications

Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease

2000 • 2,616 citations

Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

1991 • 2,186 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Primary Pulmonary Hypertension

1997 • 1,748 citations

Pulmonary Hypertension

2006 • 917 citations

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

2002 • 763 citations

Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension

2002 • 589 citations

Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain

2000 • 565 citations

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1999 • 522 citations

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

1994 • 501 citations

Cyclic nucleotide phosphodiesterases

2001 • 500 citations

Use of Sildenafil (Viagra) in Patients With Cardiovascular Disease

1999 • 497 citations

Sildenafil Inhibits Hypoxia-Induced Pulmonary Hypertension

2001 • 485 citations

Use of sildenafil (Viagra) in patients with cardiovascular disease

1999 • 452 citations

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)

1997 • 418 citations

Effect of Inhaled Iloprost Plus Oral Sildenafil in Patients With Primary Pulmonary Hypertension

2001 • 402 citations

Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension

2003 • 381 citations

Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina

1996 • 371 citations

Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass.

1993 • 371 citations

Effects of sildenafil citrate on human hemodynamics

1999 • 369 citations

Sildenafil Ameliorates Effects of Inhaled Nitric Oxide Withdrawal

1999 • 344 citations

Overall cardiovascular profile of sildenafil citrate

1999 • 313 citations

Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure

2000 • 306 citations

Sildenafil for Long-Term Treatment of Nonoperable Chronic Thromboembolic Pulmonary Hypertension

2003 • 294 citations

Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K_ATPchannels in rabbits

2002 • 291 citations

Hemodynamic Effects of Sildenafil in Men with Severe Coronary Artery Disease

2000 • 286 citations

A Stimulatory Role for cGMP-Dependent Protein Kinase in Platelet Activation

2003 • 265 citations

Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics.

1993 • 249 citations

Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature.

2002 • 230 citations

Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure

2001 • 228 citations

Effects of sildenafil on esophageal motility of patients with idiopathic achalasia

2000 • 201 citations

HEMODYNAMIC EFFECTS OF SILDENAFIL IN MEN WITH SEVERE CORONARY ARTERY DISEASE

2000 • 197 citations

Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery

2003 • 190 citations

Sildenafil Effects on Exercise, Neurohormonal Activation, and Erectile Dysfunction in Congestive Heart Failure

2002 • 182 citations

Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors

1994 • 182 citations

Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy

2001 • 181 citations

Intravenous Sildenafil Is a Potent Pulmonary Vasodilator in Children With Congenital Heart Disease

2003 • 177 citations

Sildenafil-associated nonarteritic anterior ischemic optic neuropathy

2002 • 172 citations

Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension

2001 • 171 citations

Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension

2002 • 171 citations

Therapeutic Potential of Phosphodiesterase 5 Inhibition for Cardiovascular Disease

2003 • 154 citations

Pulmonary Hypertension

2000 • 142 citations

Sildenafil augments the effect of inhaled nitric oxide for postoperative pulmonary hypertensive crises

2002 • 139 citations

Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue

2000 • 134 citations

Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury.

1994 • 133 citations

Immediate and Long-term Hemodynamic and Clinical Effects of Sildenafil in Patients With Pulmonary Arterial Hypertension Receiving Vasodilator Therapy

2003 • 125 citations

Sympathetic Activation by Sildenafil

2000 • 123 citations

Evaluation of the effect of phosphodiesterase inhibitors on mortality in chronic heart failure patients

1994 • 115 citations

Inhaled nitric oxide to test the vasodilator capacity of the pulmonary vascular bed in children with long-standing pulmonary hypertension and congenital heart disease

1996 • 114 citations

Anterior Ischemic Optic Neuropathy Associated With Viagra

2001 • 108 citations

Sildenafil for primary and secondary pulmonary hypertension

2002 • 101 citations

Effects of Sildenafil Citrate (Viagra) Combined With Nitrate on the Heart

2000 • 97 citations

Sildenafil (Viagra) associated anterior ischemic optic neuropathy.

2000 • 91 citations

Sildenafil Modulates Hemodynamics and Pulmonary Gas Exchange

2001 • 89 citations

Chronic oral sildenafil therapy in severe pulmonary artery hypertension.

2002 • 86 citations

Effect of sildenafil on blood pressure and arterial wave reflection in treated hypertensive men

2001 • 85 citations

Coronary and systemic hemodynamic effects of sildenafil citrate: from basic science to clinical studies in patients with cardiovascular disease

2002 • 83 citations

Sildenafil in HIV-related pulmonary hypertension

2001 • 81 citations

Mechanisms and implications of endothelial dysfunction in congestive heart failure

1997 • 78 citations

The effect of sildenafil on nitric oxide–mediated vasodilation in healthy men

2001 • 77 citations

Clinical trials of sildenafil citrate (Viagra) demonstrate no increase in risk of myocardial infarction and cardiovascular death compared with placebo.

2003 • 74 citations

The efficacy and tolerability of sildenafil in patients with moderate-to-severe pulmonary hypertension.

2003 • 73 citations

Sildenafil Can Increase the Response to Inhaled Nitric Oxide

2000 • 72 citations

Sildenafil citrate does not affect cardiac contractility in human or dog heart

2003 • 64 citations

CLINICAL TRIALS OF SILDENAFIL CITRATE (VIAGRA®) DEMONSTRATE NO INCREASE IN RISK OF MYOCARDIAL INFARCTION AND CARDIOVASCULAR DEATH COMPARED WITH PLACEBO

2003 • 59 citations

The pharmacology of sildenafil, a novel and selective inhibitor of phosphodiesterase (PDE) type 5

1999 • 53 citations

Cyclic Nucleotide Phosphodiesterase Type 5 Activity Limits Blood Flow to Hypoperfused Myocardium During Exercise

2000 • 52 citations

Sildenafil (viagra) facilitates weaning of inhaled nitric oxide following placement of a biventricular-assist device

2001 • 52 citations

Effects of sildenafil citrate (viagra) on cardiac repolarization and on autonomic control in subjects with chronic heart failure

2002 • 51 citations

Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension

2002 • 45 citations

Sildenafil citrate (Viagra) does not exacerbate myocardial ischemia in canine models of coronary artery stenosis

2001 • 42 citations

Cardiac Electrophysiologic and Hemodynamic Effects of Sildenafil, a PDE5 Inhibitor, in Anesthetized Dogs

2001 • 36 citations

Management of pulmonary hypertension resulting from interstitial lung disease

2003 • 34 citations

Phosphodiesterase III and V Inhibitors on Pulmonary Artery from Pulmonary Hypertensive Rats: Differences Between Early and Established Pulmonary Hypertension

1998 • 34 citations

Effect of sildenafil on coronary active and reactive hyperemia

2000 • 29 citations

Systemic lupus erythematosus-associated pulmonary hypertension: good outcome following sildenafil therapy

2003 • 26 citations

Retinal side-effects of sildenafil

1999 • 24 citations

Cardiovascular Safety of Sildenafil

2003 • 23 citations

Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers.

2001 • 16 citations

Effects of Sildenafil on Cardiopulmonary Responses During Stress

2003 • 10 citations

Sildenafil verändert nicht die koronare Flussreserve bei Diabetikern mit erektiler Dysfunktion

2003 • 6 citations

Sildenafil citrate for the treatment of patients with cardiovascular diseases with exclusion of coronary artery disease and hypertrophic subaortic stenosis. Its beneficial effect on patients chronic Chagas's and diabetic cardioneuromyopathies, hypertensive and hypertrophic cardiomyopathies, with or without chronic congestive heart failure.

2003 • 1 citations