Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study

1994 • 4,980 citations

Adenosine 3‘,5‘-Phosphate in Biological Materials

1962 • 2,102 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 • 1,187 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE BY TISSUE PARTICLES

1958 • 802 citations

Intracellular cyclic GMP receptor proteins

1993 • 655 citations

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

1998 • 595 citations

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

1996 • 591 citations

Energetics of Ligand Binding to Proteins

1975 • 519 citations

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

1996 • 473 citations

Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens

1977 • 422 citations

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)

1997 • 418 citations

Distinct and specific functions of cGMP-dependent protein kinases

1997 • 394 citations

Isolation and Characterization of PDE9A, a Novel Human cGMP-specific Phosphodiesterase

1998 • 332 citations

Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases

1995 • 313 citations

Guanylyl cyclase receptors.

1994 • 292 citations

Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

1998 • 283 citations

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

1998 • 269 citations

Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.

1992 • 269 citations

Effects of sildenafil, a type‐5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro

1997 • 257 citations

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

1990 • 232 citations

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase

1998 • 221 citations

Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae

1993 • 219 citations

[13] Nitric oxide-cyclic GMP signal transduction system

1996 • 183 citations

Characterization of a novel cGMP binding protein from rat lung.

1980 • 179 citations

Cyclic nucleotide phosphodiesterases: Structure, regulation and drug action

1991 • 176 citations

The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.

1993 • 169 citations

Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

1990 • 161 citations

Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase.

1994 • 155 citations

Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase.

1980 • 141 citations

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes

1994 • 135 citations

Structure and physiological role of cGMP-dependent protein kinase

1992 • 130 citations

Sildenafil Inhibits Phosphodiesterase Type 5 in Human Clitoral Corpus Cavernosum Smooth Muscle

1998 • 130 citations

Guanosine 3':5'-cyclic monophosphate binding proteins in rat tissues.

1976 • 129 citations

Identification of Inhibitory and Calmodulin-binding Domains of the PDE1A1 and PDE1A2 Calmodulin-stimulated Cyclic Nucleotide Phosphodiesterases

1995 • 122 citations

Cyclic-GMP-Binding, Cyclic-GMP-Specific Phosphodiesterase (PDE5) Gene Expression Is Regulated during Rat Pulmonary Development

1998 • 120 citations

Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain.

1992 • 113 citations

Expression, structure and chromosomal localization of the human cGMP‐binding cGMP‐specific phosphodiesterase PDE5A gene

1998 • 113 citations

Cyclic nucleotide phosphodiesterases : structure, regulation and drug action

1990 • 112 citations

Fortnightly review: Update on male erectile dysfunction

1998 • 100 citations

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.

1994 • 96 citations

An Essential Aspartic Acid at Each of Two Allosteric cGMP-binding Sites of a cGMP-specific Phosphodiesterase

1995 • 96 citations

Expression of Rat cGMP‐Binding cGMP‐Specific Phosphodiesterase mRNA in Purkinje Cell Layers During Postnatal Neuronal Development

1997 • 90 citations

The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung

1992 • 78 citations

Short-term feedback regulation of cAMP by accelerated degradation in rat tissues.

1987 • 75 citations

[65] Purification of cGMP-binding protein phosphodiesterase from rat lung

1988 • 73 citations

Potential Roles of Conserved Amino Acids in the Catalytic Domain of the cGMP-binding cGMP-specific Phosphodiesterase (PDE5)

1998 • 73 citations

Identification of Key Amino Acids in a Conserved cGMP-binding Site of cGMP-binding Phosphodiesterases

1996 • 70 citations

Stereochemistry of hydrolysis of adenosine 3‘:5‘-cyclic phosphorothioate by the cyclic phosphodiesterase from beef heart.

1979 • 67 citations

THE ASSAY OF GLUCAGON AND EPINEPHRINE WITH USE OF LIVER HOMOGENATES

1957 • 62 citations

Zinc Dependent Activation of cAMP-Specific Phosphodiesterase (PDE4A)

1997 • 62 citations

Phosphorylation of the 61-kDa Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase at Serine 120 Reduces Its Affinity for Calmodulin

1994 • 58 citations

Cyclic GMP : synthesis, metabolism, and function

1994 • 57 citations

The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP Phosphodiesterase

1997 • 48 citations

Purification and characterization of guanosine 3':5'-monophosphate-specific phosphodiesterase from guinea pig lung.

1977 • 47 citations

Compartmentalization of cyclic AMP phosphodiesterases, signalling ‘crosstalk’, desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP

1995 • 35 citations

Ligand-Induced Conformational Changes in Cyclic Nucleotide Phosphodiesterases and Cyclic Nucleotide-Dependent Protein Kinases

1998 • 34 citations

Dual regulation of heat‐stable enterotoxin‐mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity

1997 • 30 citations

Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase

1995 • 25 citations

18O-Labeling of guanosine monophosphate upon hydrolysis of cyclic guanosine 3‘:5‘-monophosphate by phosphodiesterase.

1980 • 23 citations

Isolation and Regulation of the cGMP-lnhibited cAMP Phosphodiesterase in Human Erythroleukemia Cells

1997 • 11 citations

Phosphodiesterase Inhibitors

1996 • 3 citations