Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Cardiac Hypertrophy: The Good, the Bad, and the Ugly

2003 • 1,410 citations

Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

2004 • 979 citations

Hypertrophy of the Heart

2004 • 817 citations

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

2000 • 778 citations

Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy

2003 • 746 citations

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

2002 • 584 citations

Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

1997 • 569 citations

Cyclic nucleotide phosphodiesterases: Relating structure and function

2000 • 565 citations

Nitric Oxide and Cardiac Function

2003 • 554 citations

Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

2003 • 499 citations

Clinical efficacy of sildenafil in primary pulmonary hypertension

2004 • 488 citations

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

2004 • 468 citations

Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

2002 • 467 citations

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

2004 • 460 citations

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

2002 • 455 citations

Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart

2002 • 438 citations

Glycogen Synthase Kinase-3β

2002 • 435 citations

Oral sildenafil in the treatment of erectile dysfunction

2002 • 406 citations

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1999 • 397 citations

Involvement of Extracellular Signal-Regulated Kinases 1/2 in Cardiac Hypertrophy and Cell Death

2002 • 387 citations

Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress

2002 • 375 citations

Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A

2003 • 335 citations

Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient mice

2001 • 305 citations

Mitochondrial ATP-Sensitive Potassium Channels Inhibit Apoptosis Induced by Oxidative Stress in Cardiac Cells

2001 • 281 citations

Regulation of Gene Expression by Cyclic GMP

2003 • 276 citations

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

2002 • 274 citations

A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy

2001 • 270 citations

Impaired cardiac hypertrophic response in Calcineurin Aβ -deficient mice

2002 • 240 citations

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

2003 • 233 citations

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

2000 • 232 citations

Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure

2001 • 228 citations

Calcineurin-Mediated Hypertrophy Protects Cardiomyocytes From Apoptosis In Vitro and In Vivo

2000 • 228 citations

cGMP Catabolism by Phosphodiesterase 5A Regulates Cardiac Adrenergic Stimulation by NOS3-Dependent Mechanism

2004 • 211 citations

Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate Tolerance

2001 • 193 citations

Akt and PI 3-Kinase Signaling in Cardiomyocyte Hypertrophy and Survival

2003 • 185 citations

Therapeutic Potential of Phosphodiesterase 5 Inhibition for Cardiovascular Disease

2003 • 154 citations

Isoproterenol Activates Extracellular Signal–Regulated Protein Kinases in Cardiomyocytes Through Calcineurin

2001 • 137 citations

Gene Transfer of cGMP-Dependent Protein Kinase I Enhances the Antihypertrophic Effects of Nitric Oxide in Cardiomyocytes

2002 • 136 citations

Glycogen Synthase Kinase-3β Regulates Growth, Calcium Homeostasis, and Diastolic Function in the Heart

2004 • 125 citations

A-Kinase Anchoring Protein AKAP220 Binds to Glycogen Synthase Kinase-3β (GSK-3β) and Mediates Protein Kinase A-dependent Inhibition of GSK-3β

2002 • 125 citations

MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq

2002 • 100 citations

Phosphorylation of Isolated Human Phosphodiesterase-5 Regulatory Domain Induces an Apparent Conformational Change and Increases cGMP Binding Affinity

2002 • 93 citations

Expression of Constitutively Active Guanylate Cyclase in Cardiomyocytes Inhibits the Hypertrophic Effects of Isoproterenol and Aortic Constriction on Mouse Hearts

2003 • 86 citations

Modulation of In Vivo Cardiac Function by Myocyte-Specific Nitric Oxide Synthase-3

2004 • 80 citations

Sildenafil citrate does not affect cardiac contractility in human or dog heart

2003 • 64 citations

Time-dependent systolic and diastolic function in mice overexpressing calcineurin

2003 • 39 citations

cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5

2003 • 38 citations

Increased Activity of cGMP-Specific Phosphodiesterase (PDE5) Contributes to Resistance to Atrial Natriuretic Peptide Natriuresis in the Pregnant Rat

2004 • 29 citations

Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts

2002 • 19 citations

The Good, the Bad, and the Ugly

2003 • 14 citations