The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Computational Method to Predict Mitochondrially Imported Proteins and their Targeting Sequences

1996 • 1,654 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

Structural basis of IAP recognition by Smac/DIABLO

2000 • 844 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Structural Basis for the Inhibition of Caspase-3 by XIAP

2001 • 763 citations

A Temperature-Dependent Switch from Chaperone to Protease in a Widely Conserved Heat Shock Protein

1999 • 747 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Structural Basis of Caspase-7 Inhibition by XIAP

2001 • 567 citations

Structural Basis of Caspase Inhibition by XIAP

2001 • 473 citations

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation

2001 • 340 citations

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.

2001 • 329 citations

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

2000 • 270 citations

Characterization of a Novel Human Serine Protease That Has Extensive Homology to Bacterial Heat Shock Endoprotease HtrA and Is Regulated by Kidney Ischemia

2000 • 223 citations

Human HtrA, an Evolutionarily Conserved Serine Protease Identified as a Differentially Expressed Gene Product in Osteoarthritic Cartilage

1998 • 209 citations

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria

2001 • 202 citations

The proteolytic procaspase activation network: an in vitro analysis

1999 • 195 citations

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.

1996 • 182 citations

TUMOUR NECROSIS FACTOR-INDUCED NECROSIS VERSUS ANTI-Fas-INDUCED APOPTOSIS IN L929 CELLS

1997 • 151 citations

A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid

2002 • 83 citations

Activation of CPP32-like Proteases Is Not Sufficient to Trigger Apoptosis: Inhibition of Apoptosis by Agents that Suppress Activation of AP24, but Not CPP32-like Activity

1997 • 82 citations

Protein identification based on matrix assisted laser desorption/ionization-post source decay-mass spectrometry

2001 • 67 citations

A Functional Role for Death Proteases in s-Myc- and c-Myc-Mediated Apoptosis

1997 • 65 citations

Expression, Purification, and Functional Analysis of the Human Serine Protease HtrA2

2000 • 59 citations