Transforming growth factor-β in breast cancer: A working hypothesis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Hyaluronan ¹

1992 • 1,787 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis

1986 • 989 citations

Lumpectomy Compared with Lumpectomy and Radiation Therapy for the Treatment of Intraductal Breast Cancer

1993 • 832 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Estrogen Receptors in Human Breast Cancer

1973 • 673 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Receptors for the TGF-β family

1992 • 638 citations

Estrogen Receptors in Human Breast Cancer

1976 • 621 citations

Induction of tenascin in healing wounds.

1988 • 563 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice.

1989 • 451 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

1990 • 398 citations

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

1993 • 367 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment.

1992 • 344 citations

Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

1995 • 334 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

Specific Interaction of Type I Receptors of the TGF-β Family with the Immunophilin FKBP-12

1994 • 321 citations

Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer.

1995 • 297 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

TGF-β receptors and actions

1994 • 291 citations

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

1993 • 276 citations

Tenascin is a stromal marker for epithelial malignancy in the mammary gland.

1987 • 273 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells.

1988 • 247 citations

Prognostic value of urokinase-type plasminogen activator in 671 primary breast cancer patients.

1992 • 239 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.

1993 • 208 citations

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma.

1993 • 208 citations

A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor

1995 • 196 citations

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells.

1996 • 195 citations

Estrogen receptor mutations in tamoxifen-resistant breast cancer.

1994 • 192 citations

Differential distribution of tenascin in the normal, hyperplastic, and neoplastic breast.

1990 • 190 citations

Inhibition of growth by transforming growth factor-beta following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses.

1992 • 176 citations

Requirement for receptor‐bound urokinase in plasmin‐dependent cellular conversion of latent TGF‐β to TGF‐β

1994 • 176 citations

The extracellular regulation of growth factor action.

1992 • 176 citations

Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression.

1993 • 165 citations

Transforming growth factor β stimulates mamary adenocarcinoma cell invasion and metastasis potential

1990 • 164 citations

Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1: Predictors of Poor Response to Tamoxifen Therapy in Recurrent Breast Cancer

1995 • 161 citations

The Royal Marsden Hospital pilot tamoxifen chemoprevention trial

1994 • 156 citations

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

1992 • 155 citations

Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines.

1995 • 155 citations

Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

1992 • 154 citations

Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells.

1994 • 151 citations

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.

1993 • 138 citations

Homomeric interactions between type II transforming growth factor-beta receptors.

1994 • 137 citations

Transforming growth factors type β1 and β2 are equipotent growth inhibitors of human breast cancer cell lines

1989 • 134 citations

Cyclin D1 (PRAD1) protein expression in breast cancer: approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene.

1995 • 127 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

Mechanisms of tamoxifen resistance

1994 • 123 citations

Transforming growth factor beta 1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice.

1991 • 121 citations

Mechanism of retinoid‐induced activation of latent transforming growth factor‐β in bovine endothelial cells

1993 • 118 citations

Prospects of chemoprevention of human cancers with the synthetic retinoid fenretinide.

1994 • 117 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors.

1993 • 114 citations

Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer.

1996 • 110 citations

Macrophage nitric oxide synthesis delays progression of ultraviolet light-induced murine skin cancers.

1993 • 109 citations

Localization of transforming growth factor-β isotypes in lesions of the human breast

1992 • 107 citations

Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells.

1989 • 102 citations

Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital

1994 • 99 citations

Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor.

1990 • 91 citations

Clinical tumour markers in lung cancer

1995 • 91 citations

Identification of frequent novel genetic alterations in small cell lung carcinoma.

1994 • 87 citations

Transforming growth factor β1 is implicated in the failure of tamoxifen therapy in human breast cancer

1991 • 84 citations

Effects of transforming growth factor β on growth of human mammary epithelial cells in culture

1989 • 76 citations

TGFβ induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects

1993 • 72 citations

Discordant transforming growth factor beta 1 RNA and protein localization during chemical carcinogenesis of the skin.

1992 • 72 citations

Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.

1994 • 71 citations

Alterations in transforming growth factor-alpha and -beta production and cell responsiveness during the progression of MCF-7 human breast cancer cells to estrogen-autonomous growth.

1994 • 69 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

Latent forms of TGF‐β: Molecular Structure and Mechanisms of Activation

2007 • 67 citations

Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue.

1995 • 66 citations

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients.

1995 • 65 citations

Tamoxifen for the Primary Prevention of Breast Cancer: A Review and Critique of the Concept and Trial

1993 • 64 citations

TGF-beta receptors: structure and function.

1994 • 63 citations

Constitutive secretion of bioactive transforming growth factor β1 by small cell lung cancer cell lines

1994 • 59 citations

Mutation Analysis of the Transforming Growth Factor β Type II Receptor in Sporadic Human Cancers of the Pancreas, Liver, and Breast

1996 • 58 citations

Expression of transforming growth factor beta ligand and receptor messenger RNAs in lung cancer cell lines.

1995 • 55 citations

Transforming growth factor beta 2 (TGF-beta 2) levels in plasma of patients with metastatic breast cancer treated with tamoxifen.

1995 • 54 citations

Growth suppression by transforming growth factor β1 of human small-cell lung cancer cell lines is associated with expression of the type II receptor

1994 • 47 citations

Expression and autoregulation of transforming growth factor β receptor mRNA in small-cell lung cancer cell lines

1996 • 46 citations

Expression of transforming growth factor β (TGFβ) receptors and expression of TGFβ1, TGFβ2 and TGFβ3 in human small cell lung cancer cell lines

1993 • 46 citations

SHORT COMMUNICATION: Phenobarbital selectively promotes initiated cells with reduced TGFβ receptor levels

1996 • 37 citations

Regulation and Role of TGFβ Production in Breast Cancer^a

1996 • 36 citations

Synthesis and secretion of transforming growth factor beta isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen

1996 • 33 citations

The role of TGF‐β production in growth inhibition of breast‐tumor cells by progestins

1995 • 30 citations

Challenges: The pharmacological manipulation of members of the transforming growth factor beta family in the chemoprevention of breast cancer

1993 • 28 citations

Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method

1994 • 26 citations

Transforming growth factor beta 1 induction is associated with transforming growth factors beta 2 and beta 3 down-modulation in 12-O-tetradecanoylphorbol-13-acetate-induced skin hyperplasia.

1993 • 22 citations

Absence of transforming growth factor‐β responsiveness in the tamoxifen growth‐inhibited human breast cancer cell line CAMA‐1

1994 • 22 citations

The effect of endocrine therapy on the levels of oestrogen and progesterone receptor and transforming growth factor-β1 in metastatic human breast cancer: an immunocytochemical study

1994 • 15 citations

Transforming growth factor-beta s in mammary tumorigenesis: promoters or antipromoters?

1995 • 15 citations

Molecular approaches to prevention and therapy of aerodigestive tract cancers.

1992 • 8 citations

Human lung cancers growing on extracellular matrix: expression of oncogenes and growth factors.

1992 • 5 citations