Stable Peptide Binding to MHC Class II Molecule Is Rapid and Is Determined by a Receptive Conformation Shaped by Prior Association with Low Affinity Peptides

Catalysis in chemistry and enzymology

1969 • 3,236 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

Enhanced Dissociation of HLA-DR-Bound Peptides in the Presence of HLA-DM

1996 • 327 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

1990 • 248 citations

Crystal Structure of I-Ak in Complex with a Dominant Epitope of Lysozyme

1998 • 245 citations

Crystal Structures of Two I-Ad–Peptide Complexes Reveal That High Affinity Can Be Achieved without Large Anchor Residues

1998 • 236 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

Kinetics of Escherichia coli B D-Lactate Dehydrogenase and Evidence for Pyruvate-controlled Change in Conformation

1968 • 166 citations

The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding

1997 • 154 citations

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

1994 • 135 citations

Formation of a Highly Peptide-Receptive State of Class II MHC

1998 • 133 citations

A kinetic intermediate in the reaction of an antigenic peptide and I–Ek

1989 • 122 citations

Structural Intermediates in the Reactions of Antigenic Peptides with MHC Molecules

1989 • 107 citations

Effect of pH on MHC class II-peptide interactions.

1992 • 101 citations

Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH.

1991 • 94 citations

pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule.

1992 • 78 citations

Sodium Dodecyl Sulfate Stability of HLA-DR1 Complexes Correlates with Burial of Hydrophobic Residues in Pocket 1

1999 • 78 citations

How MHC class II molecules work: peptide-dependent completion of protein folding

1992 • 75 citations

A structural transition in class II major histocompatibility complex proteins at mildly acidic pH.

1996 • 58 citations

Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.

1996 • 56 citations

Kinetic intermediates in the reactions between peptides and proteins of major histocompatibility complex class II.

1994 • 47 citations

pH dependence of the interaction between immunogenic peptides and MHC class II molecules. Evidence for an acidic intracellular compartment being the organelle of interaction.

1992 • 40 citations

Kinetics and specificity of peptide-MHC class II complex displacement reactions.

1994 • 36 citations

A first-order reaction controls the binding of antigenic peptides to major histocompatibility complex class II molecules.

1991 • 29 citations

Peptide binding to soluble HLA-DR4 molecules produced by insect cells.

1992 • 23 citations

Conformational changes in mouse MHC class II proteins at acidic pH

1992 • 23 citations

Reactions of Peptides with Class II Proteins of the Major Histocompatibility Complex

1995 • 19 citations