[32] Modeling of structure of human immunodeficiency virus-1 protease with substrate based on crystal structure of rous sarcoma virus protease

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

1989 • 1,155 citations

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1989 • 883 citations

Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 Å Resolution

1989 • 683 citations

A structural model for the retroviral proteases

1987 • 594 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

1990 • 524 citations

X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes

1989 • 453 citations

VIRAL PROTEINASES

1988 • 448 citations

Structural evidence for gene duplication in the evolution of the acid proteases

1978 • 406 citations

Crystal structure of a retroviral protease proves relationship to aspartic protease family

1989 • 345 citations

HTLV-III gag Protein Is Processed in Yeast Cells by the Virus pol -Protease

1986 • 289 citations

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins

1988 • 269 citations

Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.

1990 • 247 citations

Retroviral protease-like sequence in the yeast transposon Ty 1

1985 • 219 citations

Three-dimensional structure, specificity and catalytic mechanism of renin

1983 • 207 citations

Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor

1987 • 184 citations

Molecular Modeling of the HIV-1 Protease and Its Substrate Binding Site

1989 • 168 citations

Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases

1989 • 140 citations

High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes

1987 • 124 citations

On the rational design of renin inhibitors: x-ray studies of aspartic proteinases complexed with transition-state analogs

1987 • 113 citations

Comparison of the crystal structures and intersubunit interactions of human immunodeficiency and Rous sarcoma virus proteases.

1990 • 104 citations

X-ray analyses of aspartic proteinases

1990 • 89 citations

Structure of the aspartic protease from Rous sarcoma retrovirus refined at 2-.ANG. resolution

1990 • 82 citations

Comparison of inhibitor binding in HIV‐1 protease and in non‐viral aspartic proteases: the role of the flap

1990 • 75 citations

Evaluation of homology modeling of HIV Protease

1990 • 56 citations

Chemical synthesis and expression of the HIV-1 protease gene in E.coli

1989 • 47 citations

Possible role of some groups in the structure and function of HIV‐1 protease as revealed by molecular modeling studies

1989 • 23 citations

Structural alignment of retroviral protease sequences

1989 • 22 citations

The human amylase-encoding genes amy2 and amy3 are identical to AMY2A and AMY2B

1989 • 13 citations