Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

2002 • 583 citations

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

2002 • 530 citations

Glucagon-Like Peptide-1 Promotes Islet Cell Growth and Inhibits Apoptosis in Zucker Diabetic Rats

2002 • 507 citations

Glucagon-Like Peptides: Regulators of Cell Proliferation, Differentiation, and Apoptosis

2003 • 475 citations

Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats

2000 • 427 citations

Glucagon-Like Peptide 1 Induces Pancreatic β-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor

2003 • 394 citations

Glucagon-Like Peptide-1 and Exendin-4 Stimulate β-Cell Neogenesis in Streptozotocin-Treated Newborn Rats Resulting in Persistently Improved Glucose Homeostasis at Adult Age

2001 • 367 citations

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1998 • 366 citations

Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.

1999 • 326 citations

Improved Human Islet Isolation Using a New Enzyme Blend, Liberase

1997 • 303 citations

Glucagon-Like Peptide-1 Inhibits Apoptosis of Insulin-Secreting Cells via a Cyclic 5′-Adenosine Monophosphate-Dependent Protein Kinase A- and a Phosphatidylinositol 3-Kinase-Dependent Pathway

2003 • 301 citations

Insulinotropic Hormone Glucagon-Like Peptide-1 Differentiation of Human Pancreatic Islet-Derived Progenitor Cells into Insulin-Producing Cells

2002 • 301 citations

Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4

2002 • 288 citations

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases β-cell mass in diabetic mice

2002 • 280 citations

Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation

2001 • 249 citations

Regulation of beta-cell mass by hormones and growth factors.

2001 • 236 citations

Role of Endogenous Glucagon-Like Peptide-1 in Islet Regeneration After Partial Pancreatectomy

2003 • 180 citations

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.

1997 • 174 citations

Therapy of type 2 diabetes mellitus based on the actions of glucagon‐like peptide‐1

2002 • 161 citations

Transgenic Overexpression of Hepatocyte Growth Factor in the β-Cell Markedly Improves Islet Function and Islet Transplant Outcomes in Mice

2001 • 157 citations

Glucagon-like peptide 1 (1–37) converts intestinal epithelial cells into insulin-producing cells

2003 • 137 citations

β-Cell Differentiation from a Human Pancreatic Cell Line in Vitro and in Vivo

2001 • 130 citations

Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure.

1998 • 115 citations

IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

2000 • 98 citations

Factors controlling pancreatic cell differentiation and function

2001 • 85 citations

Functional Maturation of Fetal Porcine β-Cells by Glucagon-Like Peptide 1 and Cholecystokinin

2002 • 80 citations

Using β-Cell Growth Factors to Enhance Human Pancreatic Islet Transplantation*

2001 • 64 citations

Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations

2002 • 50 citations

Islet transplantation as a treatment for diabetes.

1998 • 29 citations

ENHANCED MATURATION OF PORCINE NEONATAL PANCREATIC CELL CLUSTERS WITH GROWTH FACTORS FAILS TO IMPROVE TRANSPLANTATION OUTCOME1

2001 • 27 citations

Glucagon-like Peptide 1 Increases Glucose-Dependent Activity of the Homeoprotein IDX-1 Transactivating Domain in Pancreatic β-Cells

2000 • 26 citations

Transgenic Expression of FGF8 and FGF10 Induces Transdifferentiation of Pancreatic Islet Cells into Hepatocytes and Exocrine Cells

2002 • 24 citations

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