Insulinotropic Hormone Glucagon-Like Peptide-1 Differentiation of Human Pancreatic Islet-Derived Progenitor Cells into Insulin-Producing Cells

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

Isolation of multipotent adult stem cells from the dermis of mammalian skin

2001 • 1,590 citations

Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

2001 • 1,468 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

The Glucagon-Like Peptides

1999 • 1,018 citations

Developmental biology of the pancreas

1995 • 942 citations

Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

2001 • 864 citations

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

1987 • 830 citations

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

2001 • 788 citations

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

2000 • 741 citations

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

2000 • 590 citations

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

1993 • 576 citations

Glucagon-Like Peptides

1998 • 548 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1999 • 405 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide

1993 • 371 citations

Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets

2001 • 365 citations

High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans

2001 • 328 citations

Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.

1999 • 326 citations

Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells.

1996 • 279 citations

Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

1989 • 254 citations

Transcribing pancreas.

1998 • 252 citations

Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells

2001 • 222 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells*

1999 • 202 citations

Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations

1999 • 192 citations

Insulinotropic Glucagon-Like Peptide I Receptor Expression in Glucagon-Producing α-Cells of the Rat Endocrine Pancreas

1997 • 177 citations

Early pattern of differentiation in the human pancreas.

2000 • 176 citations

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.

1998 • 173 citations

Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

2001 • 166 citations

Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats

2000 • 161 citations

POU transcription factors control expression of CNS stem cell-specific genes

1998 • 158 citations

Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus.

1996 • 152 citations

Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.

2000 • 133 citations

Neogenesis vs. apoptosis as main components of pancreatic β cell mass changes in glucose‐infused normal and mildly diabetic adult rats

1999 • 133 citations

Pancreatic β-Cell-specific Repression of Insulin Gene Transcription by CCAAT/Enhancer-binding Protein β

1997 • 123 citations

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.

1998 • 121 citations

Homeodomain Protein IDX-1

1997 • 109 citations

Tissue-specific effects of sulfonylureas

2000 • 106 citations

Science, medicine, and the future Non-insulin dependent diabetes mellitus: the gathering storm

1997 • 95 citations

POU Domain Transcription Factor brain 4 Confers Pancreatic α-Cell-Specific Expression of the Proglucagon Gene Through Interaction with a Novel Proximal Promoter G1 Element

1997 • 94 citations

Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels fromcells and extrapancreatic tissues

2000 • 75 citations

Brn-4 Transcription Factor Expression Targeted to the Early Developing Mouse Pancreas Induces Ectopic Glucagon Gene Expression in Insulin-producing β Cells

2002 • 60 citations

Antidiabetogenic action of glucagon‐like peptide‐1 related to administration relative to meal intake in subjects with type 2 diabetes

2001 • 25 citations

Cyclical Alternative Exon Splicing of Transcription Factor Cyclic Adenosine Monophosphate Response Element-Binding Protein (CREB) Messenger Ribonucleic Acid during Rat Spermatogenesis*

1998 • 24 citations

beta-cell neogenesis in type 2 diabetes.

2001 • 24 citations

Neogenesis of Pancreatic Endocrine Cells in Copper-Deprived Rat Models

2000 • 20 citations

Glucagonlike peptide-1 agonist stimulation of β-cell growth and differentiation

2001 • 16 citations

Expression of glucagon‐like peptide‐1 (GLP‐1) receptor and the effect of GLP‐1‐(7–36) amide on insulin release by pancreatic islets during rat ontogenic development

2001 • 10 citations

Deleted Work

1955 • 0 citations