Glucagon-Like Peptide-1 Inhibits Apoptosis of Insulin-Secreting Cells via a Cyclic 5′-Adenosine Monophosphate-Dependent Protein Kinase A- and a Phosphatidylinositol 3-Kinase-Dependent Pathway

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Morphologic and biochemical hallmarks of apoptosis

2000 • 1,387 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

1998 • 742 citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

1998 • 554 citations

Glucagon-Like Peptide-1 Promotes Islet Cell Growth and Inhibits Apoptosis in Zucker Diabetic Rats

2002 • 507 citations

Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats

2000 • 427 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

Protection and Reversal of Excitotoxic Neuronal Damage by Glucagon-Like Peptide-1 and Exendin-4

2002 • 354 citations

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy.

2000 • 351 citations

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

2000 • 336 citations

Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia

2000 • 244 citations

Molecular steps of death receptor and mitochondrial pathways of apoptosis

2001 • 240 citations

Glucose, Other Secretagogues, and Nerve Growth Factor Stimulate Mitogen-activated Protein Kinase in the Insulin-secreting β-Cell Line, INS-1

1995 • 222 citations

Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

1995 • 210 citations

Structure—Function Analysis of Bcl-2 Family Proteins

1996 • 204 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells*

1999 • 202 citations

Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1998 • 187 citations

Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor.

2001 • 143 citations

Pituitary Adenylyl Cyclase-activating Peptide Stimulates Extracellular Signal-regulated Kinase 1 or 2 (ERK1/2) Activity in a Ras-independent, Mitogen-activated Protein Kinase/ERK Kinase 1 or 2-dependent Manner in PC12 Cells

1997 • 127 citations

Glucose-dependent Insulinotropic Polypeptide Activates the Raf-Mek1/2-ERK1/2 Module via a Cyclic AMP/cAMP-dependent Protein Kinase/Rap1-mediated Pathway

2002 • 124 citations

Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes

1998 • 119 citations

Development of Glucagon-Like Peptide-1-Based Pharmaceuticals as Therapeutic Agents for the Treatment of Diabetes

2001 • 113 citations

Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication

1999 • 108 citations

The Glucagon-like Peptide-2 Receptor Mediates Direct Inhibition of Cellular Apoptosis via a cAMP-dependent Protein Kinase-independent Pathway

2000 • 107 citations

DNases and apoptosis

2000 • 107 citations

Hepatocyte growth factor protects cardiac myocytes against oxidative stress-induced apoptosis

2001 • 102 citations

Myeloperoxidase Is Involved in H2O2-induced Apoptosis of HL-60 Human Leukemia Cells

2000 • 90 citations

Untitled

1999 • 78 citations

HYDROGEN PEROXIDE INDUCES APOPTOSIS IN HUMAN HEPATOMA CELLS AND ALTERS CELL REDOX STATUS

2000 • 75 citations

Cell Death After Exposure to Subarachnoid Hemolysate Correlates Inversely With Expression of CuZn–Superoxide Dismutase

2000 • 73 citations

Activation of the CAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression

1999 • 72 citations

Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes

1998 • 71 citations

Using β-Cell Growth Factors to Enhance Human Pancreatic Islet Transplantation*

2001 • 64 citations

Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis

1998 • 58 citations

Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes

2001 • 55 citations

Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-Terminal protein kinase pathway

2001 • 53 citations

Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase

2001 • 51 citations

Aspects of the involvement of interleukin-1 and nitric oxide in the pathogenesis of insulin-dependent diabetes mellitus

1998 • 50 citations

cAMP-INDUCED APOPTOSIS IN GRANULOSA CELLS IS ASSOCIATED WITH UP-REGULATION OF P53 AND BAX AND DOWN-REGULATION OF CLUSTERIN

2001 • 49 citations

Hydrogen peroxide, a messenger with too many roles?

2001 • 43 citations

Apoptosis and disease progression in the spontaneously diabetic BB/S rat

2001 • 36 citations

Growth Factor Effects on Apoptosis of Rat Gastric Enterochromaffin-Like Cells¹

1998 • 34 citations

The immunohistochemical localization of Bax and Bcl-2 and their relation to apoptosis during amelogenesis in developing rat molars

2001 • 34 citations

[Type 2 diabetes and beta cell apoptosis].

2000 • 23 citations

Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosis in myeloma cell lines

2001 • 21 citations

Fas and Fas ligand-mediated apoptosis and its role in autoimmune diabetes

1998 • 20 citations

[Apoptosis-inducing and -preventing signal transduction pathways in cultured cerebellar granule neurons].

1998 • 19 citations

Transforming Growth Factor β1 Induces Apoptosis in Normal Melanocytes but not in Nevus Cells Grown in Type I Collagen Gel

2000 • 18 citations

Genetic and functional analysis of PARP, a DNA strand break-binding enzyme

2001 • 18 citations

EFFECT OF LIVER TRANSPLANTATION ON ISLET ALLOGRAFTS

2001 • 14 citations