Lymph Node Germinal Centers Form in the Absence of Follicular Dendritic Cell Networks

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Germinal Centers

1994 • 1,680 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Quantitative Image Analysis of HIV-1 Infection in Lymphoid Tissue

1996 • 604 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen

1996 • 494 citations

The Follicular Dendritic Cell: Its Role in Antigen Presentation in the Generation of Immunological Memory

1980 • 490 citations

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

1996 • 477 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

The Follicular Dendritic Cell: Long Term Antigen Retention During Immunity

1980 • 377 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.

1993 • 367 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection

1998 • 349 citations

Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

1996 • 322 citations

Follicular dendritic cells and human immunodeficiency virus infectivity

1995 • 313 citations

Dendritic cells capable of stimulating T cells in germinal centres

1996 • 309 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

1997 • 292 citations

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

1997 • 284 citations

Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1988 • 275 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells

1997 • 254 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

Lymphotoxin

1988 • 205 citations

The Evolution of B-Cell Clones

1990 • 185 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

Idiotypic analysis of the response of C57BL/6 mice to the (4‐hydroxy‐3‐nitrophenyl)acetyl group

1977 • 171 citations

Inherited Immunoglobulin Idiotypes of the Mouse

1977 • 168 citations

Functional and molecular characterization of single, (4‐hydroxy‐3‐nitrophenyl)acetyl (NP)‐specific, IgG₁⁺ B cells from antibody‐secreting and memory B cell pathways in the C57BL/6 immune response to NP

1992 • 159 citations

Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines.

1996 • 153 citations

In Situ Studies of the Germinal Center Reaction

1995 • 139 citations

Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

1997 • 131 citations

Quantitative Image Analysis of HIV-1 Infection in Lymphoid Tissue

1996 • 128 citations

Murine B cell differentiation lineages.

1984 • 124 citations

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen

1992 • 119 citations

To ‘B’ or not to ‘B’ a germinal center?

1997 • 114 citations

Triple check for antigen specificity of B cells during germinal centre reactions

1997 • 111 citations

Follicular Dendritic Cell (FDC) Precursors in Primary Lymphoid Tissues

1998 • 108 citations

The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response.

1981 • 101 citations

Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma.

1992 • 97 citations

Murine follicular dendritic cells and low affinity Fc receptors for IgE (Fc epsilon RII).

1992 • 88 citations

Activation of the lymphotoxin beta receptor by cross-linking induces chemokine production and growth arrest in A375 melanoma cells.

1997 • 78 citations

The Central Role of Follicular Dendritic Cells in Lymphoid Tissues

1992 • 75 citations

A Role for Tumor Necrosis Factor Receptor Type 1 in Gut-associated Lymphoid Tissue Development: Genetic Evidence of Synergism with Lymphotoxin β

1998 • 74 citations

Follicular dendritic cells (FDC) in retroviral infection: host/pathogen perspectives

1997 • 68 citations

Expansion, Selection and Maintenance of Memory B-Cell Clones

1990 • 66 citations

Sites of B Lymphocyte Selection, Activation, and Tolerance in Spleen

1997 • 61 citations

Complementation of Lymphotoxin α Knockout Mice with Tumor Necrosis Factor–expressing Transgenes Rectifies Defective Splenic Structure and Function

1998 • 61 citations

The use of the enzyme-linked immunosorbent assay (ELISA) for the detection and quantification of specific antibody from cell cultures.

1979 • 60 citations

Germinal centre formation and follicular antigen trapping in the spleen of lethally X-irradiated and reconstituted rats.

1986 • 54 citations

Affinity Maturation in Lyn Kinase-Deficient Mice with Defective Germinal Center Formation

1998 • 52 citations

Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands.

1995 • 47 citations

Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.

1995 • 42 citations

Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes.

1997 • 39 citations

Accumulation of somatic hypermutation and antigen‐driven selection in rapidly cycling surface Ig⁺ germinal center (GC) B cells which occupy GC at a high frequency during the primary antihapten response in mice

1997 • 32 citations

Follicular Dendritic Cells: Structure as Related to Function

1995 • 18 citations