Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Germinal Centers

1994 • 1,680 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes

1992 • 673 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

The LY‐1B Cell Lineage

1986 • 603 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.

1995 • 496 citations

The Follicular Dendritic Cell: Its Role in Antigen Presentation in the Generation of Immunological Memory

1980 • 490 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

The CD19/CR2/TAPA-1 Complex of B Lymphocytes: Linking Natural to Acquired Immunity

1995 • 469 citations

Structure and Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21)

1989 • 460 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

1992 • 400 citations

Evidence for presence of an internal thiolester bond in third component of human complement.

1980 • 368 citations

Follicular Dendritic Cells as Accessory Cells

1990 • 351 citations

CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase

1993 • 320 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

1991 • 301 citations

Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes.

1988 • 260 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

Microanatomy of Lymphoid Tissue During Humoral Immune Responses: Structure Function Relationships

1989 • 253 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

Suppression of the Immune Response by a Soluble Complement Receptor of B Lymphocytes

1991 • 242 citations

Antibody response to a T-dependent antigen requires B cell expression of complement receptors.

1996 • 236 citations

Altering Genes in Animals by Gene Targeting

1992 • 224 citations

Genomic DNA microextraction: A method to screen numerous samples

1992 • 221 citations

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

1992 • 214 citations

Complement Dependence of Localisation of Aggregated IgG in Germinal Centres

1975 • 210 citations

In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody.

1990 • 205 citations

Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.

1991 • 203 citations

Prolonged antigen half-life in the lymphoid follicles of specifically immunized mice.

1979 • 186 citations

Covalent binding and hemolytic activity of complement proteins.

1980 • 183 citations

Role of Complement in Induction of the Allergic Response

1972 • 179 citations

The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1.

1990 • 176 citations

The response of human platelets to activated components of the complement system

1991 • 175 citations

A molecular and immunochemical characterization of mouse CR2. Evidence for a single gene model of mouse complement receptors 1 and 2.

1990 • 166 citations

Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative.

1988 • 162 citations

The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them

1984 • 160 citations

Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.

1988 • 141 citations

A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP.

1988 • 132 citations

A new nomenclature for B cells

1991 • 129 citations

Immune Response of a Patient with Deficiency of the Fourth Component of Complement and Systemic Lupus Erythematosus

1979 • 119 citations

The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex.

1991 • 116 citations

Complement activation is required for IgM-mediated enhancement of the antibody response.

1988 • 103 citations

The role of complement in the induction of antibody responses.

1983 • 96 citations

Antibodies to murine complement receptor 1 and 2 can inhibit the antibody response in vivo without inhibiting T helper cell induction.

1995 • 94 citations

The germinal center reaction

1995 • 94 citations

Role of C3 in humoral immunity. Defective antibody production in C3-deficient dogs.

1988 • 91 citations

Follicular dendritic cells help resting B cells to become effective antigen-presenting cells: induction of B7/BB1 and upregulation of major histocompatibility complex class II molecules.

1993 • 86 citations

Impaired humoral immune response in complement C3-deficient guinea pigs: absence of secondary antibody response

1986 • 80 citations

Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2.

1994 • 70 citations

Identification of murine complement receptor type 2.

1989 • 63 citations

Regulatory proteins for the activated third and fourth components of complement (C3b and C4b) in mice. II. Identification and properties of complement receptor type 1 (CR1).

1985 • 47 citations

Structural differences between the two human complement C4 isotypes affect the humoral immune response.

1992 • 42 citations

Binding of C3b and C4b by the CR1-like site in murine CR1.

1994 • 30 citations

Is the follicular dendritic cell a primarily stationary cell?

1992 • 23 citations

Ligand specificities of mouse complement receptor types 1 (CR1) and 2 (CR2) purified from spleen cells

1993 • 23 citations