Epidermal growth factor and bombesin differ strikingly in the induction of early responses in Swiss 3T3 cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

The epidermal growth factor-induced calcium signal in A431 cells.

1986 • 297 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

A role for neuropeptides in the control of cell proliferation

1987 • 225 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

Inositol lipids in cell signalling.

1989 • 212 citations

Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+

1985 • 212 citations

Vasopressin stimulation of mouse 3T3 cell growth.

1979 • 210 citations

Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.

1988 • 207 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

1987 • 202 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Effects of bombesin and insulin on inositol (1,4,5) trisphosphate and inositol (1,3,4) trisphosphate formation in Swiss 3T3 cells

1986 • 185 citations

Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate.

1987 • 168 citations

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts.

1986 • 156 citations

Homologous and heterologous mitogenic desensitization of Swiss 3T3 cells to phorbol esters and vasopressin: Role of receptor and postreceptor steps

1984 • 154 citations

Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.

1986 • 132 citations

Interrelationship between growth factor-induced pH changes and intracellular Ca2+.

1987 • 128 citations

Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling

1987 • 128 citations

Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C

1987 • 127 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.

1988 • 117 citations

Protein kinase C-mediated negative-feedback inhibition of unstimulated and bombesin-stimulated polyphosphoinositide hydrolysis in Swiss-mouse 3T3 cells

1987 • 114 citations

Stimulation of Na+H+ antiport activity by epidermal growth factor and insulin occurs without activation of protein kinase C

1985 • 112 citations

Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover.

1988 • 108 citations

Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.

1986 • 101 citations

Epidermal growth factor (EGF) stimulates inositol trisphosphate formation in cells which overexpress the EGF receptor

1987 • 99 citations

EGF and insulin action in fibroblasts

1986 • 93 citations

A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts

1987 • 93 citations

EGF raises cytosolic Ca2+ in A431 and Swiss 3T3 cells by a dual mechanism

1987 • 89 citations

Insulin and epidermal growth factor do not affect phosphoinositide metabolism in rat liver plasma membranes and hepatocytes.

1985 • 85 citations

Receptor for bombesin with associated tyrosine kinase activity.

1986 • 77 citations

Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation.

1988 • 73 citations

Bicarbonate determines cytoplasmic pH and suppresses mitogen-induced alkalinization in fibroblastic cells.

1988 • 71 citations

Ca2+ and pH responses to sequential additions of mitogens in single 3T3 fibroblasts: correlations with DNA synthesis.

1988 • 67 citations

Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin

1988 • 57 citations

The Na+/H+ exchanger is constitutively activated in P19 embryonal carcinoma cells, but not in a differentiated derivative. Responsiveness to growth factors and other stimuli.

1987 • 41 citations

Increased epidermal growth factor binding to G₀‐arrested 3T3 cells

1981 • 4 citations