Molecular effects of novel mutations inHesx1/HESX1associated with human pituitary disorders

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

1996 • 787 citations

Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

1998 • 769 citations

Transcriptional selectivity of viral genes in mammalian cells

1986 • 722 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

Guidebook to the homeobox genes

1994 • 399 citations

Cooperative dimerization of paired class homeo domains on DNA.

1993 • 380 citations

Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency

2000 • 364 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA

1999 • 318 citations

Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia

2001 • 315 citations

Active repression mechanisms of eukaryotic transcription repressors

1996 • 308 citations

Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke’s pouch of the mouse embryo

1996 • 286 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo

1996 • 280 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

GAL4 derivatives function alone and synergistically with mammalian activators in vitro

1988 • 274 citations

Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed

1997 • 240 citations

Mixer , a Homeobox Gene Required for Endoderm Development

1998 • 206 citations

Direct homeodomain–DNA interaction in the autoregulation of the fushi tarazu gene

1992 • 179 citations

Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm

1998 • 176 citations

Heritable Disorders of Pituitary Development1

1999 • 174 citations

Guidebook to the Hoineobox Genes

1994 • 161 citations

Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho

1997 • 157 citations

Two Distinct Types of Repression Domain in Engrailed: One Interacts with the Groucho Corepressor and Is Preferentially Active on Integrated Target Genes

1998 • 155 citations

BMP-4-responsive regulation of dorsal–ventral patterning by the homeobox protein Mix.1

1996 • 152 citations

UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans

1999 • 126 citations

Homeodomain interactions

1996 • 125 citations

Dorsal-Mediated Repression Requires the Formation of a Multiprotein Repression Complex at the Ventral Silencer

1998 • 114 citations

Structural Determinants within Pbx1 That Mediate Cooperative DNA Binding with Pentapeptide-Containing Hox Proteins: Proposal for a Model of a Pbx1-Hox-DNA Complex

1996 • 110 citations

A synergistic increase in potency of a multimerized VP16 transcriptional activation domain.

1992 • 107 citations

Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function

2000 • 102 citations

Goosecoid and Mix.1 repress Brachyury expression and are required for head formation in Xenopus

1999 • 102 citations

Hormonal, metabolic, and neuroradiologic abnormalities associated with septo-optic dysplasia

1984 • 85 citations

Heritable Disorders of Pituitary Development

1999 • 81 citations

Interactions between an HMG-1 protein and members of the Rel family

1999 • 77 citations

A Conserved Motif in Goosecoid Mediates Groucho-Dependent Repression in Drosophila Embryos

1999 • 67 citations

Drosophila Goosecoid requires a conserved heptapeptide for repression of Paired-class homeoprotein activators

1998 • 64 citations

MR Imaging of the Pituitary Gland in Children and Young Adults with Congenital Combined Pituitary Hormone Deficiency Associated with PROP1 Mutations

2000 • 63 citations

Evidence for possible Mendelian inheritance of septo‐optic dysplasia

1996 • 60 citations

HESX1: a novel gene implicated in a familial form of septo‐optic dysplasia

1999 • 33 citations

Interactions between an HMG-4 protein and members of the Rel family

1999 • 30 citations

Factors influencing the differentiation of embryonal carcinoma and embryo-derived stem cells

1989 • 21 citations