Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

1988 • 1,325 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

1990 • 924 citations

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

1990 • 745 citations

Oct-4: a germline-specific transcription factor mapping to the mouse t-complex.

1990 • 603 citations

Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation.

1991 • 507 citations

Mouse Embryonic Stem Cells and Reporter Constructs to Detect Developmentally Regulated Genes

1989 • 491 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

1990 • 428 citations

Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo

1989 • 417 citations

Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells

1987 • 403 citations

Octamania: The POU factors in murine development

1991 • 373 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

1992 • 364 citations

Octamer binding proteins confer transcriptional activity in early mouse embryogenesis.

1989 • 338 citations

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

1991 • 333 citations

Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity

1990 • 332 citations

Prokaryotic-like cis elements in the cap-independent internal initiation of translation on picornavirus RNA

1992 • 275 citations

Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage

1990 • 271 citations

In situ hybridization; a practical approach

1993 • 194 citations

Homologous integration in mammalian cells without target gene selection.

1988 • 172 citations

Leukemia inhibitory factor: A biological perspective

1991 • 167 citations

Anin situtransgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis

1989 • 148 citations

Cardioviral internal ribosomal entry site is functional in a genetically engineered dicistronic poliovirus

1992 • 129 citations

Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations.

1990 • 126 citations

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy.

1993 • 125 citations

Differentiation inhibiting activity () and mouse development

1992 • 121 citations

Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.

1990 • 116 citations

Simple and efficient production of embryonic stem cell-embryo chimeras by coculture.

1993 • 99 citations

Developmental expression of myeloid leukemia inhibitory factor gene in preimplantation blastocysts and in extraembryonic tissue of mouse embryos.

1990 • 91 citations

A physical map of the human pseudoautosomal region.

1988 • 82 citations

Mouse embryo stem cells: their identification, propagation and manipulation

1992 • 80 citations

Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.

1990 • 67 citations

Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues

1993 • 58 citations

Embryonal Stem Cells: Introducing Planned Changes into the Animal Germline

1992 • 37 citations

Site-Directed Point Mutations in Embryonic Stem Cells: a Gene-Targeting Tag-and-Exchange Strategy

1993 • 36 citations

A rapid and efficient method for freezing and recovering clones of embryonic stem cells

1992 • 25 citations

Developmental Expression of Myeloid Leukemia Inhibitory Factor Gene in Preimplantation Blastocysts and in Extraembryonic Tissue of Mouse Embryos

1990 • 24 citations