Multiple mechanisms of N -phosphonacetyl- <scp>l</scp> -aspartate resistance in human cell lines: Carbamyl- P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

1988 • 1,334 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

Aspartate Transcarbamylase

1971 • 422 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

Rapid generation of region specific probes by chromosome microdissection and their application

1992 • 262 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1976 • 228 citations

Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of the six biosynthetic enzymes

1973 • 205 citations

DNA amplification is rare in normal human cells.

1990 • 192 citations

Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

1990 • 179 citations

Regulation and Mechanisms of Mammalian Gene Amplification

1993 • 163 citations

Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.

1992 • 163 citations

A Colon Cancer Cell Line (LIM1215) Derived From a Patient With Inherited Nonpolyposis Colorectal Cancer&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1985 • 159 citations

Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells

1990 • 136 citations

Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus.

1989 • 132 citations

Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080.

1984 • 124 citations

Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.

1992 • 108 citations

The molecular basis of fragile sites in human chromosomes

1995 • 103 citations

Genetic instability as a consequence of inappropriate entry into and Progression through S-phase

1995 • 84 citations

The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells

1993 • 79 citations

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: I. Isolation of a mutant defective in the early steps of de novo pyrimidine synthesis

1977 • 78 citations

Construction of a cDNA to the Hamster CAD Gene and Its Application Toward Defining the Domain for Aspartate Transcarbamylase

1985 • 64 citations

Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.

1983 • 48 citations

A family of cosmid vectors with the multi-copy R6K replication origin

1987 • 46 citations

Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts.

1993 • 40 citations

p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

1995 • 37 citations

Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles.

1996 • 33 citations

Transposition of human immunoglobulin V kappa genes within the same chromosome and the mechanism of their amplification.

1990 • 30 citations

Induction of gene amplification by 5-aza-2′-deoxycytidine

1992 • 26 citations

Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells

1994 • 23 citations

The propensity for gene amplification: A comparison of protocols, cell lines, and selection agents

1994 • 22 citations

Mapping of the gene encoding the multifunctional protein carrying out the first three steps of pyrimidine biosynthesis to human chromosome 2

1989 • 18 citations

Properties of Single-Step Mutants of Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

1983 • 17 citations

CAD Gene Expression in Serum-Starved and Serum-Stimulated Hamster Cells

1988 • 15 citations