Properties of Single-Step Mutants of Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

The distribution of the numbers of mutants in bacterial populations

1949 • 1,471 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

Specific Gene Amplification in Oocytes

1968 • 811 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Aspartate Transcarbamylase

1971 • 422 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells.

1981 • 314 citations

Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster

1980 • 301 citations

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1976 • 228 citations

Diazotizable arylamine cellulose papers for the coupling and hybridization of nucleic acids

1982 • 218 citations

N-(Phosphonacetyl)-l-Aspartate, a Potent Transition State Analog Inhibitor of Aspartate Transcarbamylase, Blocks Proliferation of Mammalian Cells in Culture

1974 • 217 citations

Aspartate Transcarbamylase

1970 • 99 citations

N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis.

1979 • 95 citations

Decontaminating Tissue Cultures infected with Pleuropneumonia-like Organisms

1960 • 53 citations

Tandem duplication induced by an unusual ampA1-, ampC-transducing lambda phage: A probe to initiate gene amplification

1980 • 9 citations