Two Independent Signaling Pathways Mediate the Antiapoptotic Action of Macrophage-Stimulating Protein on Epithelial Cells

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1995 • 5,334 citations

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1995 • 3,456 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

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1995 • 3,300 citations

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1994 • 3,249 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

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1997 • 2,442 citations

Role of cell shape in growth control

1978 • 2,434 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Integrins and anoikis

1997 • 1,145 citations

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1996 • 1,113 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

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1974 • 814 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

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1995 • 520 citations

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1997 • 474 citations

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1984 • 405 citations

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src

1997 • 380 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

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1996 • 371 citations

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1998 • 360 citations

Integrins, Oncogenes, and Anchorage Independence

1997 • 345 citations

A novel putative receptor protein tyrosine kinase of the met family.

1993 • 321 citations

A survey of transformation markers in differentiating epidermal cell lines in culture.

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RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.

1994 • 311 citations

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Integrins, adhesion and apoptosis

1997 • 274 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

1994 • 259 citations

Identification of the ron Gene Product as the Receptor for the Human Macrophage Stimulating Protein

1994 • 257 citations

The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway

1998 • 252 citations

Akt-Dependent and -Independent Survival Signaling Pathways Utilized by Insulin-Like Growth Factor I

1998 • 248 citations

Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

1997 • 245 citations

Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

1997 • 215 citations

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

1996 • 213 citations

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

1997 • 203 citations

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

1998 • 192 citations

Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway

1999 • 179 citations

Competitive and noncompetitive inhibition of the DNA-dependent protein kinase.

1999 • 176 citations

Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3

1993 • 174 citations

AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation

1995 • 161 citations

Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells

1994 • 146 citations

Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents

1998 • 140 citations

The Insulin-Like Growth Factor-I Receptor Signaling Pathways Are Important for Tumorigenesis and Inhibition of Apoptosis

1997 • 137 citations

Loss of Matrix Adhesion Triggers Rapid Transformation-Selective Apoptosis in Fibroblasts

1997 • 135 citations

Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002

1994 • 135 citations

Cooperation between soluble factors and integrin‐mediated cell anchorage in the control of cell growth and differentiation

1996 • 130 citations

Lack of Correlation between Activation of Jun–NH2-terminal Kinase and Induction of Apoptosis after Detachment of Epithelial Cells

1997 • 118 citations

Cell Anchorage Regulates Apoptosis through the Retinoblastoma Tumor Suppressor/E2F Pathway

1997 • 108 citations

Macrophage-Stimulating Protein Induces Proliferation and Migration of Murine Keratinocytes

1996 • 103 citations

A serum protein that stimulates macrophage movement, chemotaxis and spreading

1976 • 98 citations

Linking extracellular survival signals and the apoptotic machinery

1998 • 85 citations

Insulin-like growth factor-I-mediated survival from Anoikis: Role of cell aggregation and focal adhesion kinase

1998 • 79 citations

The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein.

1995 • 76 citations

Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein.

1996 • 74 citations

Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development

1991 • 74 citations

Isolation of macrophage stimulating protein (MSP) from human serum

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pp125FAK in the Focal Adhesion

1996 • 62 citations

Insulin/IGF-I Rescues Immortalized Brown Adipocytes from Apoptosis Down-Regulating Bcl-xS Expression, in a PI 3-Kinase- and Map Kinase-Dependent Manner

1998 • 60 citations

Specific TrkA survival signals interfere with different apoptotic pathways

1998 • 57 citations

Cell Adhesion Molecules: An Overview

1998 • 54 citations

Kinases involved in MSP/RON signaling

1999 • 51 citations

An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression

1998 • 48 citations

Endogenous FGF1-induced Activation and Synthesis of Extracellular Signal-regulated Kinase 2 Reduce Cell Apoptosis in Retinal-pigmented Epithelial Cells

1998 • 47 citations

Soluble Integrin Ligands and Growth Factors Independently Rescue Neuroblastoma Cells from Apoptosis under Nonadherent Conditions

1997 • 46 citations

Macrophage Stimulating Protein-Induced Epithelial Cell Adhesion Is Mediated by a PI3-K-Dependent, but FAK-Independent Mechanism

1999 • 33 citations