A Distinct and Parallel Pathway for the Nuclear Import of an mRNA-binding Protein

Methods in yeast genetics

1979 • 7,824 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors

1993 • 663 citations

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1997 • 654 citations

Identification of different roles for RanGDP and RanGTP in nuclear protein import.

1996 • 644 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

Distinct functions for the two importin subunits in nuclear protein import

1995 • 479 citations

The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

1995 • 460 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

A Novel Class of RanGTP Binding Proteins

1997 • 427 citations

Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.

1995 • 385 citations

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

1997 • 371 citations

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1997 • 365 citations

A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

1997 • 335 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins

1996 • 306 citations

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope.

1994 • 306 citations

A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export.

1996 • 298 citations

In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import.

1995 • 288 citations

Sequence and characterization of cytoplasmic nuclear protein import factor p97.

1995 • 274 citations

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

1995 • 264 citations

A new family of yeast nuclear pore complex proteins.

1992 • 256 citations

Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.

1995 • 254 citations

A Pre-mRNA-Binding Protein Accompanies the RNA from the Gene through the Nuclear Pores and into Polysomes

1996 • 220 citations

In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation.

1996 • 210 citations

Identification of a Yeast Karyopherin Heterodimer That Targets Import Substrate to Mammalian Nuclear Pore Complexes

1995 • 210 citations

A Yeast Acetyl Coenzyme A Carboxylase Mutant Links Very-Long-Chain Fatty Acid Synthesis to the Structure and Function of the Nuclear Membrane-Pore Complex

1996 • 200 citations

Nucleocytoplasmic transport of macromolecules

1997 • 191 citations

Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p.

1995 • 184 citations

Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.

1995 • 168 citations

NAB2: a Yeast Nuclear Polyadenylated RNA-Binding Protein Essential for Cell Viability

1993 • 167 citations

Role of the Nuclear Transport Factor p10 in Nuclear Import

1996 • 166 citations

A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm.

1994 • 164 citations

Karyopherin β2 mediates nuclear import of a mRNA binding protein

1997 • 160 citations

Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants [published erratum appears in J Cell Biol 1994 Sep;126(6):1627]

1994 • 159 citations

The yeast nuclear import receptor is required for mitosis.

1995 • 153 citations

Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β

1997 • 146 citations

The Essential Yeast Nucleoporin NUP159 Is Located on the Cytoplasmic Side of the Nuclear Pore Complex and Serves in Karyopherin-mediated Binding of Transport Substrate

1995 • 139 citations

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.

1994 • 133 citations

Dynamic localization of the nuclear import receptor and its interactions with transport factors.

1996 • 127 citations

The Nuclear Transport Factor Karyopherin β Binds Stoichiometrically to Ran-GTP and Inhibits the Ran GTPase Activating Protein

1996 • 123 citations

A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast.

1992 • 119 citations

Peptide-Mass Profiles of Polyvinylidene Difluoride-Bound Proteins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry in the Presence of Nonionic Detergents

1996 • 113 citations

NOP3 is an essential yeast protein which is required for pre-rRNA processing.

1992 • 111 citations

RNA TRANSPORT

1997 • 110 citations

Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

1996 • 105 citations

mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.

1995 • 101 citations

Interaction between the Small GTPase Ran/Gsp1p and Ntf2p Is Required for Nuclear Transport

1997 • 98 citations

Potential RNA Binding Proteins in Saccharomyces cerevisiae Identified as Suppressors of Temperature-Sensitive Mutations in NPL3

1996 • 91 citations

mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm

1997 • 88 citations

A yeast protein that bidirectionally affects nucleocytoplasmic transport

1995 • 75 citations

A Yeast RNA-Binding Protein Shuttles between the Nucleus and the Cytoplasm

1994 • 69 citations

Mammalian karyopherin α_1β and α_2β heterodimers : α_1 or α_2 bind nuclear localization signal and β interacts with peptide repeat containing nucleoporins

1995 • 5 citations