Oxygen-Dependent and -Independent Regulation of HIF-1alpha

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

1999 • 2,168 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

1991 • 932 citations

HIF-1 and human disease: one highly involved factor

2000 • 900 citations

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

1992 • 811 citations

HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia

2001 • 714 citations

Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction

2000 • 689 citations

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1998 • 653 citations

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1999 • 645 citations

Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

2000 • 635 citations

Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

1998 • 633 citations

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

1997 • 605 citations

Expression of hypoxia-inducible factor 1? in brain tumors

2000 • 596 citations

The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology

2001 • 584 citations

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

1998 • 572 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

2001 • 550 citations

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1997 • 514 citations

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

2000 • 421 citations

Induction of hypoxia‐inducible factor‐1 (HIF‐1) and its target genes following focal ischaemia in rat brain

1999 • 412 citations

Activation of the HIF pathway in cancer

2001 • 403 citations

VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis

1996 • 342 citations

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

1998 • 333 citations

Structural and functional analysis of hypoxia-inducible factor 1

1997 • 311 citations

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

1999 • 295 citations

Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway

2002 • 282 citations

Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3α

2001 • 267 citations

A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α

2001 • 265 citations

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

1991 • 260 citations

Accumulation of HIF-1α under the influence of nitric oxide

2001 • 257 citations

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1α and NF-κB Redox Sensitivity

2000 • 237 citations

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.

1998 • 231 citations

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1998 • 230 citations

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

1998 • 228 citations

Early Expression of Myocardial HIF-1α in Response to Mechanical Stresses

2002 • 227 citations

Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene

1991 • 209 citations

Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide

2001 • 207 citations

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

1997 • 197 citations

Effect of Altered Redox States on Expression and DNA-Binding Activity of Hypoxia-Inducible Factor 1

1995 • 171 citations

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells11Abbreviations: EPO, erythropoietin; VEGF, vascular endothelial growth factor; HIF, hypoxia-inducible factor; NO, nitric oxide; NOS, nitric oxide synthase; CO, carbon monoxide; sGC, soluble guanylate cyclase; cGMP, cyclic GMP; YC-1, 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole; SNP, sodium nitroprusside; ODQ, 1H-(1,2,4)oxadiazole (4,3a)quinoxatin-1-one; MB, methylene blue…

2001 • 146 citations

Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors

1999 • 139 citations

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

2002 • 108 citations

Assessment of HER2 status in breast cancer

2000 • 108 citations

Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor Pathway for Adventitial Vasa Vasorum Formation in Hypertensive Rat Aorta

2002 • 101 citations

Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt

1979 • 68 citations

Oxygen equilibrium study and light absorption spectra of Ni(II)Fe(II) hybrid hemoglobins

1986 • 62 citations

Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.

2002 • 62 citations

Molecular aspects of oxygen sensing in physiological adaptation to hypoxia

1997 • 60 citations

Properties of chemically modified Ni(II)Fe(II) hybrid hemoglobins

1986 • 58 citations

Zinc Induces the Accumulation of Hypoxia-Inducible Factor (HIF)-1α, but Inhibits the Nuclear Translocation of HIF-1β, Causing HIF-1 Inactivation

2000 • 58 citations

Role of Exon 2-encoded β-Domain of the von Hippel-Lindau Tumor Suppressor Protein

2001 • 56 citations

Ischemic preconditioning reduces O2.- generation and prevents respiratory impairment in the mitochondria of post-ischemic reperfused heart of rat

1997 • 54 citations

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

2000 • 38 citations

Drosophila von Hippel-Lindau Tumor Suppressor Complex Possesses E3 Ubiquitin Ligase Activity

2000 • 34 citations