Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
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References (60)
p53 Mutations in Human Cancers
1991 • 8,133 citations
Mdm2 promotes the rapid degradation of p53
1997 • 4,336 citations
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
1998 • 3,026 citations
Radical causes of cancer
2003 • 1,611 citations
Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
1998 • 1,566 citations
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
1994 • 1,426 citations
A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay
1994 • 1,332 citations
HIF-1 and tumor progression: pathophysiology and therapeutics
2002 • 1,025 citations
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
1998 • 818 citations
Roles of nitric oxide in tumor growth.
1995 • 791 citations
The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O 2
2000 • 696 citations
Nitric oxide synthase activity in human breast cancer
1995 • 637 citations
A Tutorial on the Diffusibility and Reactivity of Free Nitric Oxide
1997 • 496 citations
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.
1998 • 471 citations
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.
1996 • 455 citations
Nitric oxide synthase activity in human gynecological cancer.
1994 • 428 citations
MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
1998 • 402 citations
YC-1, a novel activator of platelet guanylate cyclase
1994 • 401 citations
Expression of nitric oxide synthase in human central nervous system tumors.
1995 • 370 citations
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
2002 • 346 citations
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.
1995 • 326 citations
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells
1998 • 279 citations
Prognostic significance of tumor oxygenation in humans
2003 • 258 citations
Accumulation of HIF-1α under the influence of nitric oxide
2001 • 257 citations
Nitric oxide is an important mediator for tumoricidal activity in vivo.
1994 • 249 citations
Nitric oxide in cancer and chemoprevention
2003 • 208 citations
Involvement of Hypoxia-Inducible Factor 1 in Human Cancer.
2002 • 206 citations
Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells.
1994 • 195 citations
Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas.
2000 • 194 citations
Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): Potential role of cyclin D1
2001 • 175 citations
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice
1998 • 166 citations
Induction of Hypoxia-Inducible-Factor 1 by Nitric Oxide Is Mediated via the PI 3K Pathway
2000 • 133 citations
Nitric oxide‐mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen‐activated protein kinase
2003 • 125 citations
Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors.
1999 • 119 citations
Recent advances in insulin gene therapy for type 1 diabetes
2002 • 113 citations
The Role of Nitric Oxide (NO) in Stability Regulation of Hypoxia Inducible Factor-1α (HIF-1α)
2003 • 107 citations
Role of Mitogen-Activated Protein Kinases inS-Nitrosoglutathione-Induced Macrophage Apoptosis
1999 • 99 citations
Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the ApcMin/+ mouse
2001 • 96 citations
Nitrosative Capacity of Macrophages Is Dependent on Nitric-oxide Synthase Induction Signals
2000 • 93 citations
MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer.
2003 • 89 citations
Suppression of Tumorigenicity and Metastasis of Human Renal Carcinoma Cells by Infection with Retroviral Vectors Harboring the Murine Inducible Nitric Oxide Synthase Gene
1998 • 89 citations
Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy
2002 • 82 citations
Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease.
1997 • 79 citations
Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin‐1 secretion
1995 • 75 citations
Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa
1994 • 75 citations
Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems
2002 • 73 citations
Rapid and Delayed p42/p44 Mitogen-Activated Protein Kinase Activation by Nitric Oxide: The Role of Cyclic GMP and Tyrosine Phosphatase Inhibition
1998 • 69 citations
Transcription factors p53 and HIF-1α as targets of nitric oxide
2001 • 68 citations
Role of nitric oxide in tumour progression with special reference to a murine breast cancer model
2002 • 66 citations
Endothelial Nitric Oxide Synthase: Correlation with Histologic Grade, Lymph Node Status and Estrogen Receptor Expression in Human Breast Cancer
2000 • 60 citations
Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion
2001 • 57 citations
Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.
2001 • 54 citations
Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase
2003 • 51 citations
Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase.
2003 • 51 citations
Nitric Oxide Synthase Type 3 is Increased in Squamous Hyperplasia, Dysplasia, and Squamous Cell Carcinoma of the Head and Neck
1999 • 44 citations
Endothelial constitutive nitric oxide synthase (ecNOS) localization in normal and neoplastic salivary tissue
1998 • 33 citations
Predictors of distant metastasis at presentation in breast cancer: a study also evaluating associations among common biological indicators
2001 • 33 citations
The C-Terminal Half of Heat Shock Protein 90 Represents a Second Site for Pharmacologic Intervention in Chaperone Function
2003 • 30 citations
The use of altered specificity mutants to probe specific protein–protein interactions involved in the activation of GATA-1 target genes
2002 • 29 citations
Cytoplasmic Localization of Endothelial Constitutive Nitric Oxide Synthase in Endometrial Carcinomas
1997 • 22 citations