Investigating hypoxic tumor physiology through gene expression patterns

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

1998 • 1,567 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

1996 • 1,081 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

2001 • 1,012 citations

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1996 • 930 citations

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

2002 • 754 citations

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

2000 • 754 citations

Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

2002 • 707 citations

Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

2002 • 689 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer

2001 • 655 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

2001 • 602 citations

Hypoxia and drug resistance

1994 • 555 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

1997 • 459 citations

Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13

2002 • 454 citations

Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.

1993 • 445 citations

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1999 • 387 citations

Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia

1998 • 379 citations

ENDOTHELIAL CELL RESPONSES TO HYPOXIC STRESS

1999 • 371 citations

Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

2001 • 347 citations

Nix and Nip3 Form a Subfamily of Pro-apoptotic Mitochondrial Proteins

1999 • 298 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

2000 • 265 citations

Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α

2002 • 260 citations

Von Hippel-Lindau Syndrome

1999 • 257 citations

Hypoxia-associated Induction of Early Growth Response-1 Gene Expression

1999 • 250 citations

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia

1998 • 224 citations

In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction

1993 • 198 citations

Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.

1998 • 194 citations

Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia

1998 • 180 citations

Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway

1998 • 177 citations

Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1

2001 • 161 citations

Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction

2002 • 153 citations

Crystal Structure of Negative Cofactor 2 Recognizing the TBP-DNA Transcription Complex

2001 • 152 citations

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

1996 • 151 citations

Functional versatility in the CRP-FNR superfamily of transcription factors: FNR and FLP

2001 • 148 citations

Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development

1999 • 117 citations

Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential‐Display PCR

1996 • 113 citations

Thrombospondin-1 Is Downregulated by Anoxia and Suppresses Tumorigenicity of Human Glioblastoma Cells

2000 • 110 citations

Oxygen-mediated Regulation of Tumor Cell Invasiveness

2002 • 95 citations

Induction of Adrenomedullin by Hypoxia and Cobalt Chloride in Human Colorectal Carcinoma Cells

1998 • 94 citations

Absolute Requirement of Aryl Hydrocarbon Receptor Nuclear Translocator Protein for Gene Activation by Hypoxia

1996 • 91 citations

Relationship of hypoxia to metastatic ability in rodent tumours

2001 • 88 citations

Mitogen‐inducible gene 6 (MIG‐6), adipophilin and tuftelin are inducible by hypoxia

2002 • 86 citations

The yeast transcriptome in aerobic and hypoxic conditions: effects of hap1, rox1, rox3 and srb10 deletions

2002 • 84 citations

Hypoxia Regulates Osteoblast Gene Expression

2001 • 79 citations

Regulation of hypoxic gene expression in yeast

1997 • 75 citations

Hypoxia Regulation of Gene Transcription

2001 • 68 citations

Regulatory elements of the erythropoietin gene

1991 • 61 citations

Hypoxia Actively Represses Transcription by Inducing Negative Cofactor 2 (Dr1/DrAP1) and Blocking Preinitiation Complex Assembly

2003 • 50 citations

Exposure of cultured primary rat astrocytes to hypoxia results in intracellular glucose depletion and induction of glycolytic enzymes

1999 • 49 citations

Oxygen regulated 80 kDa protein and glucose regulated 78 kDa protein are identical

1991 • 45 citations

Lack of Collagen Type Specificity for Lysyl Hydroxylase Isoforms

2000 • 36 citations

p53 Checkpoint-Defective Cells Are Sensitive to X Rays, but Not Hypoxia

2000 • 25 citations

Regulation of Ionic Conductances and Gene Expression by Hypoxia in an Oxygen Sensitive Cell Line

1996 • 17 citations

Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway

1998 • 13 citations

Regulatory elements of the erythropoietin gene

1991 • 4 citations

Jesus and the Twelve

2001 • 2 citations