MicroRNAs: new regulators of immune cell development and function

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

MicroRNA signatures in human cancers

2006 • 7,358 citations

MicroRNA genes are transcribed by RNA polymerase II

2004 • 4,200 citations

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

2006 • 4,019 citations

A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

2007 • 3,587 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

2003 • 2,893 citations

RNA silencing in plants

2004 • 2,393 citations

The microRNA Registry

2003 • 2,203 citations

Signaling to NF-κB by Toll-like receptors

2007 • 2,120 citations

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

2005 • 2,046 citations

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

2004 • 1,827 citations

Requirement of bic/microRNA-155 for Normal Immune Function

2007 • 1,807 citations

MicroRNA-155 is induced during the macrophage inflammatory response

2007 • 1,765 citations

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

2008 • 1,544 citations

Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex

2006 • 1,510 citations

Regulation of the Germinal Center Response by MicroRNA-155

2007 • 1,476 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

2005 • 1,324 citations

Widespread microRNA repression by Myc contributes to tumorigenesis

2007 • 1,300 citations

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

2008 • 1,212 citations

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

2008 • 1,151 citations

miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection

2007 • 1,147 citations

MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb

2007 • 1,022 citations

A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis

2005 • 979 citations

Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice

2006 • 913 citations

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

2006 • 835 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells

2007 • 762 citations

MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation

2005 • 762 citations

BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

2005 • 676 citations

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

2008 • 669 citations

Aberrant T cell differentiation in the absence of Dicer

2005 • 620 citations

miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely

2007 • 602 citations

Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage

2008 • 572 citations

The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation

2006 • 569 citations

A viral microRNA functions as an orthologue of cellular miR-155

2007 • 568 citations

Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state

2007 • 530 citations

A role for Dicer in immune regulation

2006 • 514 citations

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

2007 • 510 citations

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer

2005 • 504 citations

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin

2008 • 503 citations

CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control

2007 • 500 citations

MicroRNA silencing through RISC recruitment of eIF6

2007 • 497 citations

Dynamic regulation of miRNA expression in ordered stages of cellular development

2007 • 481 citations

miRNA Profiling of Naïve, Effector and Memory CD8 T Cells

2007 • 470 citations

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

2008 • 457 citations

Post-transcriptional regulation of microRNA expression

2006 • 457 citations

MicroRNAs 17-5p–20a–106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation

2007 • 448 citations

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

2008 • 445 citations

Kaposi's Sarcoma-Associated Herpesvirus Encodes an Ortholog of miR-155

2007 • 441 citations

MicroRNA profiling of the murine hematopoietic system.

2005 • 428 citations

MicroRNAs: Critical Regulators of Development, Cellular Physiology and Malignancy

2005 • 425 citations

MicroRNA fingerprints during human megakaryocytopoiesis

2006 • 400 citations

Epigenetic Silencing of the Myelopoiesis Regulator microRNA-223 by the AML1/ETO Oncoprotein

2007 • 388 citations

Loss of mir-146a function in hormone-refractory prostate cancer

2008 • 381 citations

MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia

2007 • 370 citations

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway

2007 • 344 citations

MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors

2008 • 331 citations

An Evolutionarily Conserved Mechanism for MicroRNA-223 Expression Revealed by MicroRNA Gene Profiling

2007 • 322 citations

Epstein-Barr Virus Latent Membrane Protein 1 Induces Cellular MicroRNA miR-146a, a Modulator of Lymphocyte Signaling Pathways

2007 • 301 citations

The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation

2007 • 283 citations

bic, a Novel Gene Activated by Proviral Insertions in Avian Leukosis Virus-Induced Lymphomas, Is Likely To Function through Its Noncoding RNA

1997 • 280 citations

Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb

2003 • 267 citations

MicroRNA-155 Is an Epstein-Barr Virus-Induced Gene That Modulates Epstein-Barr Virus-Regulated Gene Expression Pathways

2008 • 258 citations

Raising the estimate of functional human sequences: Figure 1.

2007 • 237 citations

High expression of B‐cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma

2003 • 236 citations

MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis

2007 • 204 citations

Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis

2007 • 199 citations

Epstein-Barr Virus-Encoded Latent Membrane Protein 1 (LMP1) Induces the Expression of the Cellular MicroRNA miR-146a

2007 • 195 citations

T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC

2002 • 184 citations

Genome-wide Mapping of RELA(p65) Binding Identifies E2F1 as a Transcriptional Activator Recruited by NF-κB upon TLR4 Activation

2007 • 178 citations

MicroRNA expression dynamics during murine and human erythroid differentiation

2007 • 167 citations

Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma

2006 • 138 citations

New perspectives in B-1 B cell development and function

2006 • 137 citations

Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells

2007 • 118 citations

Deleted Work

1955 • 0 citations