Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

1990 • 475 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.

1995 • 374 citations

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

1996 • 372 citations

Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines

1993 • 367 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodies

1988 • 308 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

1995 • 231 citations

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.

1996 • 223 citations

In vitro activation of Stat3 by epidermal growth factor receptor kinase

1996 • 195 citations

Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone

1995 • 180 citations

Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus

1993 • 177 citations

Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.

1995 • 139 citations

Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter.

1993 • 131 citations

IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s).

1996 • 79 citations

Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA.

1994 • 76 citations

Isolation and Characterization of the Human gp130 Promoter

1997 • 59 citations

The genomic structure and chromosomal localization of the mouse STAT3 gene

1996 • 30 citations