Status of Cytomegalovirus Prevention and Treatment in 2000

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

1992 • 1,227 citations

A controlled trial

1971 • 982 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

T CELL MEMORY

1998 • 863 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Risk Factors for Cytomegalovirus Infection after Human Marrow Transplantation

1986 • 803 citations

Viral Strategies of Immune Evasion

1998 • 791 citations

The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL

1996 • 711 citations

Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease

1991 • 686 citations

Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study

1996 • 677 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Hematopoietic Cell Transplantation

2015 • 664 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

A Randomized, Controlled Trial of Prophylactic Ganciclovir for Cytomegalovirus Pulmonary Infection in Recipients of Allogeneic Bone Marrow Transplants

1991 • 640 citations

In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine

1989 • 632 citations

Cytotoxic T Cells in Cytomegalovirus Infection

1982 • 610 citations

Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution

2000 • 597 citations

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.

1997 • 560 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

Cytomegalovirus Pneumonia after Bone Marrow Transplantation Successfully Treated with the Combination of Ganciclovir and High-Dose Intravenous Immune Globulin

1988 • 499 citations

Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation

1995 • 469 citations

Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus.

1988 • 462 citations

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity

1987 • 432 citations

The kinetics of immune reconstitution after human marrow transplantation

1987 • 428 citations

Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs

1985 • 417 citations

Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8⁺ virus‐specific cytotoxic T lymphocytes

1994 • 359 citations

Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.

1995 • 332 citations

Implication of γδ T cells in the human immune response to cytomegalovirus

1999 • 316 citations

Targeting p53 as a general tumor antigen.

1995 • 315 citations

Intravenous Immune Globulin for Prevention of Cytomegalovirus Infection and Interstitial Pneumonia After Bone Marrow Transplantation

1987 • 302 citations

Target Structures of the CD8⁺-T-Cell Response to Human Cytomegalovirus: the 72-Kilodalton Major Immediate-Early Protein Revisited

1999 • 291 citations

Cytomegalovirus selectively blocks antigen processing and presentation of its immediate–early gene product

1996 • 287 citations

Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides

1978 • 271 citations

Development of a Candidate HLA A*0201 Restricted Peptide-Based Vaccine Against Human Cytomegalovirus Infection

1997 • 268 citations

Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells

1999 • 267 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Immunity Induced By Primary Human Cytomegalovirus Infection Protects Against Secondary Infection Among Women Of Childbearing Age

1995 • 259 citations

Human cytomegalovirus-specific cytotoxic T cells. Relative frequency of stage-specific CTL recognizing the 72-kD immediate early protein and glycoprotein B expressed by recombinant vaccinia viruses.

1988 • 255 citations

A Subunit Cytomegalovirus Vaccine Based on Recombinant Envelope Glycoprotein B and a New Adjuvant

1999 • 239 citations

Peptide-induced antiviral protection by cytotoxic T cells.

1991 • 238 citations

Increased Incidence of Cytomegalovirus Disease After Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation

1999 • 235 citations

Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression.

1991 • 235 citations

Cytomegalovirus Immune Plasma in Bone Marrow Transplant Recipients

1982 • 231 citations

Reconstitution of the T-Cell Compartment After Bone Marrow Transplantation: Restoration of the Repertoire by Thymic Emigrants

1998 • 223 citations

DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines.

1996 • 221 citations

TOWNE-VACCINE-INDUCED PREVENTION OF CYTOMEGALOVIRUS DISEASE AFTER RENAL TRANSPLANTS

1984 • 218 citations

Reconstruction of the haemopoietic and immune systems after marrow transplantation.

1990 • 210 citations

The Memory Cytotoxic T-Lymphocyte (CTL) Response to Human Cytomegalovirus Infection Contains Individual Peptide-Specific CTL Clones That Have Undergone Extensive Expansion In Vivo

1999 • 210 citations

Essential Role of the Thymus to Reconstitute Naive (CD45RA+) T-Helper Cells After Human Allogeneic Bone Marrow Transplantation

1997 • 204 citations

Effect of Towne Live Virus Vaccine on Cytomegalovirus Disease after Renal Transplant

1991 • 201 citations

Immunisation with canarypox virus expressing rabies glycoprotein

1992 • 184 citations

Human Virus-Specific CD8+ CTL Clones Revert from CD45ROhigh to CD45RAhigh In Vivo: CD45RAhighCD8+ T Cells Comprise Both Naive and Memory Cells

1999 • 173 citations

MHC molecules as peptide receptors

1993 • 169 citations

Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes

1999 • 166 citations

Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease.

1996 • 163 citations

Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms

1999 • 152 citations

Early occurrence of human cytomegalovirus infection after bone marrow transplantation as demonstrated by the polymerase chain reaction technique

1991 • 152 citations

DNA Immunization with Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination

1998 • 148 citations

Systemic cytokine profiles in BALB/c mice immunized with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants.

1994 • 146 citations

The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection

1992 • 145 citations

Cytotoxic T Lymphocyte (CTL) Responses to Human Cytomegalovirus pp65, IE1‐Exon4, gB, pp150, and pp28 in Healthy Individuals: Reevaluation of Prevalence of IE1‐Specific CTLs

2000 • 144 citations

Preemptive CD8 T-Cell Immunotherapy of Acute Cytomegalovirus Infection Prevents Lethal Disease, Limits the Burden of Latent Viral Genomes, and Reduces the Risk of Virus Recurrence

1998 • 142 citations

Identification of Three HLA-A*0201-Restricted Cytotoxic T Cell Epitopes in the Cytomegalovirus Protein pp65 That Are Conserved Between Eight Strains of the Virus

1999 • 141 citations

Efficiency of peptides and lipopeptides for in vivo priming of virus‐specific cytotoxic T cells

1991 • 141 citations

Human CD28−CD8+ T Cells Contain Greatly Expanded Functional Virus-Specific Memory CTL Clones

1999 • 137 citations

Multiepitopic B- and T-Cell Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine

2000 • 137 citations

The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection.

1997 • 137 citations

Delineation of several DR-restricted tetanus toxin T cell epitopes.

1989 • 136 citations

Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope

1991 • 135 citations

Cytomegalovirus (CMV)–Specific T Cell Immunity after Renal Transplantation Mediates Protection from CMV Disease by Limiting the Systemic Virus Load

1999 • 134 citations

Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation.

1998 • 131 citations

Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells

1998 • 129 citations

Altered Helper T Lymphocyte Function Associated with Chronic Hepatitis B Virus Infection and its Role in Response to Therapeutic Vaccination in Humans

1999 • 128 citations

Large clonal expansions of human virus‐specific memory cytotoxic T lymphocytes within the CD57⁺ CD28^– CD8⁺ T‐cell population

1999 • 127 citations

A Canarypox Vector Expressing Cytomegalovirus (CMV) Glycoprotein B Primes for Antibody Responses to a Live Attenuated CMV Vaccine (Towne)

1999 • 126 citations

Lipopeptide immunization without adjuvant induces potent and long‐lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees

1997 • 124 citations

Multicenter Comparison of the Digene Hybrid Capture CMV DNA Assay (Version 2.0), the pp65 Antigenemia Assay, and Cell Culture for Detection of Cytomegalovirus Viremia

1999 • 120 citations

Recognition of Human Cytomegalovirus Gene Products by HCMV-Specific Cytotoxic T Cells

1996 • 120 citations

Selective interference with class I major histocompatibility complex presentation of the major immediate-early protein following infection with human cytomegalovirus

1993 • 119 citations

Identification of a neutralizing epitope on glycoprotein gp58 of human cytomegalovirus

1989 • 119 citations

Cytomegalovirus (CMV)-Specific Intravenous Immunoglobulin for the Prevention of Primary CMV Infection and Disease after Marrow Transplant

1991 • 111 citations

MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.

1997 • 110 citations

Population coverage by HLA class-I restricted cytotoxic T-lymphocyte epitopes

2001 • 110 citations

T cell memory. Long-term persistence of virus-specific cytotoxic T cells.

1989 • 109 citations

Dense Bodies of Human Cytomegalovirus Induce both Humoral and Cellular Immune Responses in the Absence of Viral Gene Expression

2000 • 108 citations

Late Cytomegalovirus Disease in Marrow Transplantation Is Predicted by Virus Load in Plasma

1997 • 104 citations

Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.

1993 • 104 citations

T cell therapy of human CMV and EBV infection in immunocompromised hosts

1997 • 102 citations

HLA gene and haplotype frequencies in bone marrow donors worldwide registries

1997 • 99 citations

Immunization of mice with lipopeptides bypasses the prerequisite for adjuvant. Immune response of BALB/c mice to human immunodeficiency virus envelope glycoprotein.

1992 • 99 citations

Deoxyribonucleic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes.

1997 • 98 citations

CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.

1998 • 97 citations

CHARACTERIZATION OF CMVpp65-SPECIFIC CD8+ T LYMPHOCYTES USING MHC TETRAMERS IN KIDNEY TRANSPLANT PATIENTS AND HEALTHY PARTICIPANTS1

2000 • 94 citations

Simultaneous Ex Vivo Expansion of Cytomegalovirus and Epstein-Barr Virus–Specific Cytotoxic T Lymphocytes Using B-Lymphoblastoid Cell Lines Expressing Cytomegalovirus pp65

1999 • 91 citations

Safety and immunogenicity of the Towne strain cytomegalovirus vaccine

1998 • 89 citations

A computer program for predicting possible cytotoxic T lymphocyte epitopes based on HLA class I peptide-binding motifs

1995 • 85 citations

The role of CD4 and CD8 T cells in viral infections

1991 • 84 citations

Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.

1992 • 83 citations

Generation of Cytomegalovirus-Specific Human T-Lymphocyte Clones by Using Autologous B-Lymphoblastoid Cells with Stable Expression of pp65 or IE1 Proteins: a Tool To Study the Fine Specificity of the Antiviral Response

2000 • 79 citations

Kinetics of the Antibody Response against Human Cytomegalovirus–Specific Proteins in Allogeneic Bone Marrow Transplant Recipients

1998 • 79 citations

Induction of CTL response by a minimal epitope vaccine in HLA A∗0201/DR1 transgenic mice: dependence on HLA class II restricted TH response

2000 • 76 citations

Synthetic lipopeptides as novel adjuvants

1992 • 74 citations

Specific Cellular and Humoral Immunity after Immunization with Live Towne Strain Cytomegalovirus Vaccine

1981 • 73 citations

Fine specificity of cytotoxic T lymphocytes primed in vivo either with virus or synthetic lipopeptide vaccine or primed in vitro with peptide.

1991 • 73 citations

Development of a Treatment Regimen for Human Cytomegalovirus (CMV) Infection in Bone Marrow Transplantation Recipients by Adoptive Transfer of Donor‐Derived CMV‐Specific T Cell Clones Expanded In Vitro^a

1991 • 73 citations

The Enhanced Immune Response to the HIV gp160/LAMP Chimeric Gene Product Targeted to the Lysosome Membrane Protein Trafficking Pathway

1997 • 72 citations

Phenotypic and functional reconstitution of peripheral blood lymphocytes following T cell-depleted bone marrow transplantation from partially mismatched related donors

1998 • 70 citations

Fine specificity of cellular immune responses in humans to human cytomegalovirus immediate-early 1 protein

1991 • 64 citations

A recombinant subunit vaccine approach to HCMV vaccine development.

1991 • 61 citations

A Risk-Adapted Approach with a Short Course of Ganciclovir to Prevent Cytomegalovirus (CMV) Pneumonia in CMV-Seropositive Recipients of Allogeneic Bone Marrow Transplants

1997 • 61 citations

Induction of human cytomegalovirus (HCMV)-glycoprotein B (gB)-specific neutralizing antibody and phosphoprotein 65 (pp65)-specific cytotoxic T lymphocyte responses by naked DNA immunization

1999 • 60 citations

Immunisation trials with live attenuated cytomegalovirus TOWNE 125

1975 • 60 citations

Simian immunodeficiency virus as a model for vaccination against HIV. Induction in rhesus macaques of GAG- or NEF-specific cytotoxic T lymphocytes by lipopeptides.

1994 • 59 citations

Failure to prevent cytomegalovirus infection by cytomegalovirus hyperimmune plasma: a randomized trial by the Nordic Bone Marrow Transplantation Group.

1987 • 57 citations

Histopathological studies on the local reactions induced by complete fReund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P₃C) conjugates

1991 • 55 citations

Lipopeptide particles as the immunologically active component of CTL inducing vaccines

1999 • 52 citations

Characterisation and phase behaviour of phospholipid bilayers adsorbed on spherical polysaccharidic nanoparticles

1997 • 51 citations

Therapeutic Reconstitution of Human Viral Immunity by Adoptive Transfer of Cytotoxic T Lymphocyte Clones

1994 • 47 citations

THE PHENOTYPE AND RECONSTITUTION OF IMMUNOREGULATORY T CELL SUBSETS AFTER T CELL-DEPLETED ALLOGENEIC AND AUTOLOGOUS BONE MARROW TRANSPLANTATION

1994 • 46 citations

Epitope Repertoire of Human CD4+ T Cells on Tetanus Toxin: Identification of Immunodominant Sequence Segments

1997 • 38 citations

Cytotoxic T lymphocytes from HLA-A2 transgenic mice specific for HLA-A2 expressed on human cells.

1988 • 37 citations

Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation

1995 • 36 citations

Prevention of cytomegalovirus disease by Towne strain live attenuated vaccine.

1984 • 36 citations

Minimal phenotype panels

1996 • 34 citations

Value of Different Assays for Detection of Human Cytomegalovirus (HCMV) in Predicting the Development of HCMV Disease in Human Immunodeficiency Virus-Infected Patients

2000 • 33 citations

Preemptive ganciclovir administration based solely on asymptomatic pulmonary cytomegalovirus infection in allogeneic bone marrow transplant recipients: long-term follow-up.

1995 • 33 citations

Practical protocol for cytomegalovirus isolation: use of MRC-5 cell monolayers incubated for 2 weeks

1983 • 32 citations

Evaluation of Murex CMV DNA Hybrid Capture Assay for Detection and Quantitation of Cytomegalovirus Infection in Patients following Allogeneic Stem Cell Transplantation

1998 • 31 citations

The Use of Transgenic Mice to Generate High Affinity p53 Specific Cytolytic T Cells

1997 • 31 citations

Reconstitution of the B cell repertoire after bone marrow transplantation does not recapitulate human fetal development

1999 • 29 citations

Combination of human cytomegalovirus recombinant immediate-early protein (IE1) with 80 nm cationic biovectors: protection from proteolysis and potentiation of presentation to CD4+ T-cell clones in vitro

1996 • 25 citations

Immunogenicity and HIV-1 virus neutralization of MN recombinant glycoprotein 120/HIV-1 QS21 vaccine in baboons .

1994 • 23 citations

Relevance and potential of natural killer cells in stem cell transplantation

2000 • 22 citations

Transition of T cell receptor gamma/delta expressing double negative (CD4-/CD8-) lymphocytes after allogeneic bone marrow transplantation.

1994 • 18 citations

Vaccination of Seropositive Subjects with CHIRON CMV gB Subunit Vaccine Combined with MF59 Adjuvant for Production of CMV Immune Globulin

2000 • 16 citations

Advances in CMV Diagnostic Testing and Their Implications for the Management of CMV Infection in Transplant Recipients

2001 • 4 citations

Deleted Work

1955 • 0 citations