Decreased ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus

1989 • 792 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

1990 • 546 citations

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

1988 • 413 citations

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

1993 • 350 citations

The Ras signal transduction pathway

1994 • 345 citations

Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.

1998 • 336 citations

DNA Methylation: Molecular Biology and Biological Significance

1993 • 306 citations

Isolation and characterization of the cDNA encoding human DNA methyltransferase

1992 • 250 citations

Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice.

1996 • 233 citations

Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.

1995 • 209 citations

Regulation of DNA Methylation by the Ras Signaling Pathway

1995 • 190 citations

Phenotypic and functional similarities between 5‐azacytidine‐treated t cells and a t cell subset in patients with active systemic lupus erythematosus

1992 • 178 citations

TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.

1995 • 168 citations

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1996 • 138 citations

Growth regulation of mouse DNA methyltransferase gene expression

1991 • 137 citations

Procainamide inhibits DNA methyltransferase in a human T cell line.

1991 • 136 citations

Regulation of the DNA Methyltransferase by the Ras-AP-1 Signaling Pathway

1995 • 136 citations

Lymphocyte function—associated antigen 1 overexpression and t cell autoreactivity

1994 • 124 citations

Mechanisms of drug‐induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo

1997 • 117 citations

Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis.

1993 • 115 citations

The T cell enigma in lupus

1996 • 106 citations

5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases

1991 • 98 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.

1994 • 90 citations

Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene

1996 • 90 citations

Role of the ras-MAPK Signaling Pathway in the DNA Methyltransferase Response to DNA Hypomethylation

1998 • 76 citations

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

1990 • 66 citations

Oncogene expression in autoimmune and normal peripheral blood mononuclear cells.

1986 • 65 citations

Molecular Regulation of the IL‐2 Gene: Rheostatic Control of the Immune System

1993 • 64 citations

CpG Islands

1993 • 61 citations

Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity.

1997 • 45 citations

Arthritis and Allied Conditions

1980 • 39 citations

Increased immunoglobulin response to γ-interferon by lymphocytes from patients with systemic lupus erythematosus

1988 • 38 citations

T lymphocyte immune dysfunctions in systemic lupus erythematosus.

1990 • 25 citations

Analysis of proteins that interact with the IL-2 regulatory region in patients with rheumatic diseases

1995 • 25 citations