Analysis of human peripheral blood T cells and single-cell-derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

DNA hypomethylation leads to elevated mutation rates

1998 • 935 citations

CpG methylation, chromatin structure and gene silencing---a three-way connection

1998 • 791 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

1990 • 546 citations

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

1988 • 413 citations

A genomic scanning method for higher organisms using restriction sites as landmarks.

1991 • 351 citations

Creation of genomic methylation patterns

1996 • 313 citations

Dependence of transcriptional repression on CpG methylation density.

1994 • 294 citations

Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos

1999 • 237 citations

Mutagenic and epigenetic effects of DNA methylation

1997 • 219 citations

Altered DNA methylation and genome instability: A new pathway to cancer?

1997 • 204 citations

Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS–M

1996 • 195 citations

DNA demethylation and pericentromeric rearrangements of chromosome 1

1997 • 176 citations

Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells

1998 • 171 citations

Dependence of Transcriptional Repression on CpG Methylation Density

1994 • 112 citations

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

1990 • 66 citations

Preferential induction of chromosome 1 multibranched figures and whole-arm deletions in a human pro-B cell line treated with 5-azacytidine or 5-azadeoxycytidine

1997 • 64 citations

Demethylation of repetitive DNA sequences in neuroblastoma

1996 • 56 citations

Interclonal variation in methylation patterns for expressed and non-expressed genes

1982 • 52 citations

Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity.

1997 • 45 citations

A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines

1989 • 44 citations

A methylated human 9-kb repetitive sequence on acrocentric chromosomes is homologous to a subtelomeric repeat in chimpanzees.

1996 • 44 citations

Choice of enzymes for mapping based on CpG islands in the human genome

1992 • 43 citations

Genetic variation detected by quantitative analysis of end-labeled genomic DNA fragments.

1994 • 41 citations

Increased immunoglobulin response to γ-interferon by lymphocytes from patients with systemic lupus erythematosus

1988 • 38 citations

High yield of restriction fragment length polymorphisms in two-dimensional separations of human genomic DNA

1995 • 37 citations

NotI Linking Clones as a Tool for Joining Physical and Genetic Maps of the Human Genome

1994 • 32 citations

Detection and Isolation of a Novel Human Gene Located on Xp11.2–p11.4 That Escapes X-Inactivation Using a Two-Dimensional DNA Mapping Method

1998 • 19 citations

Two-Dimensional Separation and Cloning of Chromosome 1NotI–EcoRV-Derived Genomic Fragments

1996 • 12 citations

Identification of amplifications, deletions and methylation changes in cancer by means of two-dimensional analysis of genomic digests: application to neuroblastoma

1997 • 10 citations